Predatory cone snails (genus Conus) produce a rich array of venoms that collectively contain
an estimated 100,000 small, disulfide-rich peptides (ie, conotoxins, or conopeptides). Over …

Over two decades of research on venom peptides derived from cone snails (“conopeptides or
conotoxins”) has led to several compounds that have reached human clinical trials, most of …

In the oceans, secondary metabolites often protect otherwise poorly defended invertebrates,
such as shell-less mollusks, from predation. The origins of these metabolites are largely …

Prey shifts in carnivorous predators are events that can initiate the accelerated generation
of new biodiversity. However, it is seldom possible to reconstruct how the change in prey …

We describe a functional profiling strategy to identify and characterize subtypes of neurons
present in a peripheral ganglion, which should be extendable to neurons in the CNS. In this …

Formation of the vertebrate neuromuscular junction (NMJ) takes place in a stereotypic pattern
in which nerves terminate at select sarcolemmal sites often localized to the central region …

Change is intrinsic to nervous systems; change is required for learning and conditioning
and occurs with disease progression, normal development, and aging. To better understand …

Constellation pharmacology is a cell-based high-content phenotypic-screening platform that
utilizes subtype-selective pharmacological agents to elucidate the cell-specific …

Different types of neurons diverge in function because they express their own unique set or
constellation of signaling molecules, including receptors and ion channels that work in …

The α-conotoxin family is comprised of peptides that share the following arrangement of
cysteine residues in the primary amino acid sequence: –CC–C–C–, where each dash …