The multifunctional growth factor scatter factor/hepatocyte growth factor (SF/HGF) and its
receptor tyrosine kinase c-Met have emerged as key determinants of brain tumor growth and …

The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis, …

XL-184 (BMS-907351), under development by Exelixis Inc and Bristol-Myers Squibb Co, is
a pan-tyrosine kinase inhibitor for the potential oral treatment of medullary thyroid cancer, …

microRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few
have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (…

MicroRNA-34a (miR-34a) is a transcriptional target of p53 that is down-regulated in some
cancer cell lines. We studied the expression, targets, and functional effects of miR-34a in brain …

We recently found that microRNA-34a (miR-34a) is downregulated in human glioma tumors
as compared to normal brain, and that miR-34a levels in mutant-p53 gliomas were lower …

DMT1 (divalent metal transporter 1) is a hydrogen-coupled divalent metal transporter with a
substrate preference for iron, although the protein when expressed in frog oocytes transports …

Little is known of microRNA interactions with cellular pathways. Few reports have associated
microRNAs with the Notch pathway, which plays key roles in nervous system development …

The multifunctional growth factor scatter factor/hepatocyte growth factor (SF/HGF) and its
receptor c‐met have been implicated in the genesis, malignant progression, and chemo/…

MicroRNAs and cancer stem cells have emerged as critical players in glioblastoma, one of
the deadliest human cancers. In this study, we investigated the expression and function of …