The SPOT-synthesis technique: synthetic peptide arrays on membrane supports—principles and applications
R Frank - Journal of immunological methods, 2002 - Elsevier
… of up to 10,000 peptides and other compounds in a special circular r/ϕ-array format (Fig. 5).
… onto a turning surface with the size of a CompactDisk resulting in a circular r/ϕ-array format. …
… onto a turning surface with the size of a CompactDisk resulting in a circular r/ϕ-array format. …
Clinical biomarkers in drug discovery and development
R Frank, R Hargreaves - Nature reviews Drug discovery, 2003 - nature.com
Biomarkers enable the characterization of patient populations and quantitation of the extent
to which new drugs reach intended targets, alter proposed pathophysiological mechanisms …
to which new drugs reach intended targets, alter proposed pathophysiological mechanisms …
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
H Hampel, R Frank, K Broich, SJ Teipel… - Nature reviews Drug …, 2010 - nature.com
Advances in therapeutic strategies for Alzheimer's disease that lead to even small delays in
onset and progression of the condition would significantly reduce the global burden of the …
onset and progression of the condition would significantly reduce the global burden of the …
[BOOK][B] Passions within reason: The strategic role of the emotions.
RH Frank - 1988 - psycnet.apa.org
… "Passions Within Reason" re-evaluates the traditional models of human behavior in light
of "a simple paradox," as Frank states, "namely, that in many situations the conscious …
of "a simple paradox," as Frank states, "namely, that in many situations the conscious …
Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ
R Bravo, R Frank, PA Blundell, H Macdonald-Bravo - Nature, 1987 - nature.com
… A nuclear protein called cyclin of relative molecular mass 36,000 (M r 36K), whose synthesis
correlates with the proliferative state of the cell, has been identified in several cell types of …
correlates with the proliferative state of the cell, has been identified in several cell types of …
[HTML][HTML] Prevalence and treatment of mental disorders, 1990 to 2003
… R and of the DSM-IV differ too greatly to justify direct comparisons of prevalence in the data
from the NCS and NCS-R… that was developed for the NCS-R and then applied (imputed) to …
from the NCS and NCS-R… that was developed for the NCS-R and then applied (imputed) to …
The return of Phineas Gage: clues about the brain from the skull of a famous patient
H Damasio, T Grabowski, R Frank, AM Galaburda… - Science, 1994 - science.org
When the landmark patient Phineas Gage died in 1861, no autopsy was performed, but his
skull was later recovered. The brain lesion that caused the profound personality changes for …
skull was later recovered. The brain lesion that caused the profound personality changes for …
A molecular switch and proton wire synchronize the active sites in thiamine enzymes
Thiamine diphosphate (ThDP) is used as a cofactor in many key metabolic enzymes. We
present evidence that the ThDPs in the two active sites of the E1 (EC 1.2.4.1) component of the …
present evidence that the ThDPs in the two active sites of the E1 (EC 1.2.4.1) component of the …
The epidemiology of co‐occurring addictive and mental disorders: implications for prevention and service utilization
…, KA McGonagle, MJ Edlund, RG Frank… - American journal of …, 1996 - Wiley Online Library
General population data from the National Comorbidity Survey are presented on co‐occurring
DSM‐III‐R addictive and mental disorders. Co‐occurrence is highly prevalent in the …
DSM‐III‐R addictive and mental disorders. Co‐occurrence is highly prevalent in the …
Does studying economics inhibit cooperation?
RH Frank, T Gilovich, DT Regan - Journal of economic perspectives, 1993 - aeaweb.org
In this paper we investigate whether exposure to the self-interest model commonly used in
economics alters the extent to which people behave in self-interested ways. First, we report …
economics alters the extent to which people behave in self-interested ways. First, we report …