Long-term potentiation--a decade of progress?

RC Malenka, RA Nicoll - Science, 1999 - science.org
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental
model for the synaptic changes that may underlie learning and memory. This review …

Endocannabinoid signaling in the brain

RI Wilson, RA Nicoll - science, 2002 - science.org
The primary psychoactive ingredient in cannabis, Δ 9 -tetrahydrocannabinol (Δ 9 -THC),
affects the brain mainly by activating a specific receptor (CB1). CB1 is expressed at high levels …

[PDF][PDF] AMPA receptor trafficking at excitatory synapses

DS Bredt, RA Nicoll - Neuron, 2003 - cell.com
… viewed in Nicoll, 2003) raises the possibility that the mental evidence for this first came in …
knockout mouse, in which the number of synaptic AMPA is, the R residue in GluR2 impedes …

Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses

RI Wilson, RA Nicoll - Nature, 2001 - nature.com
Marijuana affects brain function primarily by activating the G-protein-coupled cannabinoid
receptor-1 (CB1) 1 , 2 , 3 , which is expressed throughout the brain at high levels 4 . Two …

Evidence for silent synapses: implications for the expression of LTP

JTR Isaac, RA Nicoll, RC Malenka - Neuron, 1995 - Elsevier
… ., 1988; Muller and Lynch, 1989; Zalutsky and Nicoll, 1990; Manabe et al., 1993) and the
MK801-induced decay of NMDAR EPSCs (Manabe and Nicoll, 1994), we think that the current …

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

…, RC Malenka, RA Nicoll… - Proceedings of the …, 1999 - National Acad Sciences
Autosomal dominant forms of familial Alzheimer’s disease (FAD) are associated with
increased production of the amyloid β peptide, Aβ42, which is derived from the amyloid protein …

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

…, Y Kawasaki, RJ Wenthold, DS Bredt, RA Nicoll - Nature, 2000 - nature.com
Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate)
receptors on cerebellar granule cells. Stargazin, the …

[PDF][PDF] Increased expression of α-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

…, B Onoa, MK Lee, FA Chaudhry, RA Nicoll… - Neuron, 2010 - cell.com
The protein α-synuclein accumulates in the brain of patients with sporadic Parkinson's disease
(PD), and increased gene dosage causes a severe, dominantly inherited form of PD, but …

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

…, JA Kauer, DJ Perkel, MD Mauk, PT Kelly, RA Nicoll… - Nature, 1989 - nature.com
THE phenomenon of long-term potentiation (LTP), a long lasting increase in the strength of
synaptic transmission which is due to brief, repetitive activation of excitatory afferent fibres, is …

AG Protein Couples Serotonin and GABAB Receptors to the Same Channels in Hippocampus

R Andrade, RC Malenka, RA Nicoll - Science, 1986 - science.org
R. Andrade and RA Nicoll, inpreparation. The CAl region of the hippocampus is highly
enriched in 5-HTla bindingsites which are located on the pyramidal cells[A. Pazos and JM …