During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity — …

* Center for the Study of Nervous System Injury Department of Neurology Washington University
Medical School as well as the molecules that mediate specific types of responses, are …

The neurotrophin family of neurotrophic factors are well-known for their effects on neuronal
survival and growth. Over the past decade, considerable evidence has accumulated from …

The inability of axons to regenerate after a spinal cord injury in the adult mammalian central
nervous system (CNS) can lead to permanent paralysis. At sites of CNS injury, a glial scar …

Mammalian cells fuel their growth and proliferation through the catabolism of two main
substrates: glucose and glutamine. Most of the remaining metabolites taken up by proliferating …

Homologous recombination was utilized to generate mice wlth a deletion in the coding
seguence of the nerve growth factor (NGF) gene. Animals homozygous for NGF disruption failed …

Extracellular ATP is implicated in numerous sensory processes ranging from the response to
pain to the regulation of motility in visceral organs 1 . The ATP receptor P2X 3 is selectively …

Many damage-sensing neurons express tetrodotoxin (TTX)-resistant voltage-gated sodium
channels. Here we examined the role of the sensory-neuron-specific (SNS) TTX-resistant …

The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle
progression in higher eukaryotes. This report describes the isolation of a novel, highly …

Immunocytochemistry has been used to examine the location of trkA, the high‐affinity receptor
for nerve growth factor, in adult rat dorsal root ganglia, trigeminal ganglia and spinal cord. …