Structural Requirements for Eszopiclone and Zolpidem Binding to the γ-Aminobutyric Acid Type-A (GABAA) Receptor Are Different

SM Hanson, EV Morlock, KA Satyshur… - Journal of medicinal …, 2008 - ACS Publications
The sleep-aids zolpidem and eszopiclone exert their effects by binding to and modulating γ-aminobutyric
acid type-A receptors (GABA A Rs), but little is known about the structural …

Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin

SM Hanson, DJ Francis… - Proceedings of the …, 2006 - National Acad Sciences
Arrestins regulate signaling and trafficking of G protein-coupled receptors by virtue of their
preferential binding to the phosphorylated active form of the receptor. To identify sites in …

Crystal structure of cone arrestin at 2.3 Ċ: evolution of receptor specificity

…, SA Vishnivetskiy, J Robert, SM Hanson… - Journal of molecular …, 2005 - Elsevier
Arrestins play a fundamental role in the regulation and signal transduction of G protein-coupled
receptors. Here we describe the crystal structure of cone arrestin at 2.3Å resolution. The …

[HTML][HTML] Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue

…, D Roberts, A Kharitonenkov, B Zhang, SM Hanson… - Scientific reports, 2013 - nature.com
Myocardial ischemia, while causing cardiomyocyte injury, can activate innate protective
processes, enhancing myocardial tolerance to ischemia. Such processes are present in not only …

Cold Acclimation, Diapause, and Geographic Origin Affect Cold Hardiness in Eggs of Aedes albopictus (Diptera: Culicidae)

SM Hanson, GB Craig Jr - Journal of medical entomology, 1994 - academic.oup.com
Eggs of five strains of Aedes albopictus (Skuse) were obtained in both diapause and
nondiapause conditions and exposed to various cold acclimation regimes in the laboratory, after …

Comparison of Student Retention Models in Undergraduate Education From the Past Eight Decades.

F Manyanga, A Sithole, SM Hanson - Journal of Applied Learning in Higher …, 2017 - ERIC
Student retention and completion rates are challenging issues in higher education. In the
academic domain, pressure exists for every institution to come up with strategies that support …

[HTML][HTML] Light-dependent redistribution of arrestin in vertebrate rods is an energy-independent process governed by protein-protein interactions

KS Nair, SM Hanson, A Mendez, EV Gurevich… - Neuron, 2005 - cell.com
In rod photoreceptors, arrestin localizes to the outer segment (OS) in the light and to the
inner segment (IS) in the dark. Here, we demonstrate that redistribution of arrestin between …

Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity

SM Hanson, WM Cleghorn, DJ Francis… - Journal of molecular …, 2007 - Elsevier
Arrestins regulate the activity and subcellular localization of G protein-coupled receptors and
other signaling molecules. Here, we demonstrate that arrestins bind microtubules (MTs) in …

The functional cycle of visual arrestins in photoreceptor cells

VV Gurevich, SM Hanson, X Song… - Progress in retinal and …, 2011 - Elsevier
Visual arrestin-1 plays a key role in the rapid and reproducible shutoff of rhodopsin signaling.
Its highly selective binding to light-activated phosphorylated rhodopsin is an integral part of …

Structural mechanisms underlying benzodiazepine modulation of the GABAA receptor

SM Hanson, C Czajkowski - Journal of Neuroscience, 2008 - Soc Neuroscience
Many clinically important drugs target ligand-gated ion channels; however, the mechanisms
by which these drugs modulate channel function remain elusive. Benzodiazepines (BZDs), …