Nitric oxide (NO) has been linked to numerous physiological and pathophysiological events
that are not readily explained by the well established effects of NO on soluble guanylyl …

Genetically encoded sensors are powerful tools for imaging intracellular metabolites and
signaling molecules. However, developing sensors is challenging because they require …

Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues
resulting in an adduct called a nitrosothiol. Here, we describe a novel method for detecting …

Methylation of the N 6 position of adenosine (m 6 A) is a posttranscriptional modification of
RNA with poorly understood prevalence and physiological relevance. The recent discovery …

Green fluorescent protein (GFP) and its derivatives have transformed the use and analysis
of proteins for diverse applications. Like proteins, RNA has complex roles in cellular function …

RNA methylation to form N 6 -methyladenosine (m 6 A) in mRNA accounts for the most
abundant mRNA internal modification and has emerged as a widespread regulatory mechanism …

N 6 -methyladenosine (m 6 A) is a modified base that has long been known to be present in
non-coding RNAs, ribosomal RNA, polyadenylated RNA and at least one mammalian mRNA…

In recent years, m 6 A has emerged as an abundant and dynamically regulated modification
throughout the transcriptome. Recent technological advances have enabled the …

Protein translation typically begins with the recruitment of the 43S ribosomal complex to the
5′ cap of mRNAs by a cap-binding complex. However, some transcripts are translated in a …

The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional
silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly …