Role of AIF in caspase-dependent and caspase-independent cell death
The major challenge in treating cancer is that many tumor cells carry mutations in key
apoptotic genes such as p53, Bcl family proteins or those affecting caspase signaling. Such …
apoptotic genes such as p53, Bcl family proteins or those affecting caspase signaling. Such …
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
SP Cregan, A Fortin, JG MacLaurin… - The Journal of cell …, 2002 - rupress.org
Caspase-independent death mechanisms have been shown to execute apoptosis in many
types of neuronal injury. P53 has been identified as a key regulator of neuronal cell death …
types of neuronal injury. P53 has been identified as a key regulator of neuronal cell death …
Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
SP Cregan, JG MacLaurin, CG Craig… - Journal of …, 1999 - Soc Neuroscience
p53 is a pivotal molecule regulating the death of neurons both after acute injury and during
development. The molecular mechanisms by which p53 induces apoptosis in neuronal cells, …
development. The molecular mechanisms by which p53 induces apoptosis in neuronal cells, …
Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4–CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA
…, SM Callaghan, DS Park, SP Cregan - Journal of …, 2010 - Soc Neuroscience
An increasing body of evidence points to a key role of endoplasmic reticulum (ER) stress in
acute and chronic neurodegenerative conditions. Extensive ER stress can trigger neuronal …
acute and chronic neurodegenerative conditions. Extensive ER stress can trigger neuronal …
[HTML][HTML] Extension of human cell lifespan by nicotinamide phosphoribosyltransferase
…, C Ho, C O'Neil, N Barbosa, R Scott, SP Cregan… - Journal of Biological …, 2007 - ASBMB
Extending the productive lifespan of human cells could have major implications for diseases
of aging, such as atherosclerosis. We identified a relationship between aging of human …
of aging, such as atherosclerosis. We identified a relationship between aging of human …
Dysregulated bioenergetics: a key regulator of joint inflammation
…, T McGarry, W Gao, J McCormick, S Cregan… - Annals of the …, 2016 - ard.bmj.com
Objectives This study examines the relationship between synovial hypoxia and cellular
bioenergetics with synovial inflammation. Methods Primary rheumatoid arthritis synovial …
bioenergetics with synovial inflammation. Methods Primary rheumatoid arthritis synovial …
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
A Fortin, SP Cregan, JG MacLaurin… - The Journal of cell …, 2001 - rupress.org
p53 is a transcriptional activator which has been implicated as a key regulator of neuronal cell
death after acute injury. We have shown previously that p53-mediated neuronal cell death …
death after acute injury. We have shown previously that p53-mediated neuronal cell death …
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms
…, L Melanson-Drapeau, SP Cregan… - Journal of …, 2005 - Soc Neuroscience
Mitochondria release proteins that propagate both caspase-dependent and caspase-independent
cell death pathways. AIF (apoptosis-inducing factor) is an important caspase-…
cell death pathways. AIF (apoptosis-inducing factor) is an important caspase-…
[HTML][HTML] Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival
…, J Guadagno, R Bergeron, SP Cregan… - Nature …, 2014 - nature.com
Sustained cellular function and viability of high-energy demanding post-mitotic cells rely on
the continuous supply of ATP. The utilization of mitochondrial oxidative phosphorylation for …
the continuous supply of ATP. The utilization of mitochondrial oxidative phosphorylation for …
Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis
…, SSG Ferguson, A Strasser, SP Cregan - Journal of …, 2007 - Soc Neuroscience
Oxidative stress has been implicated as a key trigger of neuronal apoptosis in stroke and
neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease and …
neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease and …