… In conclusion, this study is the first to describe the regional and cellular localization of melatonin
somatodendritic receptors MT 1 and MT 2 in the rat brain. The different localization of MT …

Melatonin activates two brain G-protein coupled receptors, MT 1 and MT 2 , whose differential
roles in the sleep–wake cycle remain to be defined. The novel MT 2 receptor partial …

Pharmacological blockade of the anandamide-degrading enzyme, fatty acid amide
hydrolase (FAAH), produces CB 1 receptor (CB 1 R)-mediated analgesic, anxiolytic-like and …

Neuropathic pain is an important public health problem for which only a few treatments are
available. Preclinical studies show that melatonin (MLT), a neurohormone acting on MT1 and …

The interaction between genes and environment plays a significant role in the pathogenesis
of major depression and mood disorders. Preclinical and clinical studies have established …

Background: Melancholic depression, described also as endogenous depression, is a mood
disorder with distinctive specific psychopathological features and biological homogeneity, …

Direct evidence that dopamine (DA) neurotransmission varies during the 24 h of the day is
lacking. Here, we have characterized the firing activity of DA neurons located in the ventral …

Melatonin is a neurohormone involved in the regulation of both acute and chronic pain
whose mechanism is still not completely understood. We have recently demonstrated that …

The increase in dopamine (DA) neurotransmission stimulated by in vivo cocaine exposure
is tempered by G protein-dependent inhibitory feedback mechanisms in DA neurons of the …

… The neurotrophic factor neuregulin-1 (NRG1) is involved in many aspects of brain development,
from cell fate determination to neuronal maturation. However, nothing is known about …