TARP redundancy is critical for maintaining AMPA receptor function
K Menuz, JL O'Brien, S Karmizadegan… - Journal of …, 2008 - Soc Neuroscience
Transmembrane AMPA receptor regulatory proteins (TARPs) are AMPA receptor auxiliary
subunits that influence diverse aspects of receptor function. However, the full complement of …
subunits that influence diverse aspects of receptor function. However, the full complement of …
LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes
N Sheng, MA Bemben, J Díaz-Alonso… - Proceedings of the …, 2018 - National Acad Sciences
… Long-term potentiation (LTP) is a persistent strengthening of synaptic transmission in the
brain and is arguably the most compelling cellular and molecular model for learning and …
brain and is arguably the most compelling cellular and molecular model for learning and …
Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors
J Schwenk, N Harmel, G Zolles, W Bildl, A Kulik… - Science, 2009 - science.org
Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane
AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the …
AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the …
Stargazin promotes closure of the AMPA receptor ligand-binding domain
DM MacLean, SS Ramaswamy, M Du… - Journal of General …, 2014 - rupress.org
… where τ is the time constant for inhibition from Eq. 1 for a given concentration of NBQX… is
the forward rate constant for binding in M −1 s −1 , and k off is the rate constant for unbinding in s …
the forward rate constant for binding in M −1 s −1 , and k off is the rate constant for unbinding in s …
[HTML][HTML] … of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) receptor subunit GluA2 from the endoplasmic reticulum is stimulated by a complex …
W Lu, L Khatri, EB Ziff - Journal of Biological Chemistry, 2014 - ASBMB
… We show that upon Ca 2+ release from the ER via the IP3 and ryanodine receptors, CaMKII
that is activated enters a complex that contains PICK1, dependent upon the PICK1 BAR (Bin-…
that is activated enters a complex that contains PICK1, dependent upon the PICK1 BAR (Bin-…
The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits
At excitatory synapses in the brain, glutamate released from nerve terminals binds to
glutamate receptors to mediate signaling between neurons. Glutamate receptors expressed in …
glutamate receptors to mediate signaling between neurons. Glutamate receptors expressed in …
Expression and Development of TARP γ-4 in Embryonic Zebrafish
… One such family of proteins is the transmembrane AMPAR-related proteins, known as
TARPs. Little is known about the role of TARPs during development or about their function in …
TARPs. Little is known about the role of TARPs during development or about their function in …
A three-step model for the synaptic recruitment of AMPA receptors
The amount of AMPARs at synapses is not a fixed number but varies according to different
factors including synaptic development, activity and disease. Because the number of …
factors including synaptic development, activity and disease. Because the number of …
Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors
JS Martenson, S Tomita - Current opinion in pharmacology, 2015 - Elsevier
… One challenge in studying mechanisms of AMPAR synaptic localization is that the number
of AMPARs at synapses is dynamically regulated during synaptic plasticity [38]. Recent …
of AMPARs at synapses is dynamically regulated during synaptic plasticity [38]. Recent …
[HTML][HTML] TARP γ-2 is required for inflammation-associated AMPA receptor plasticity within lamina II of the spinal cord dorsal horn
SJ Sullivan, M Farrant, SG Cull-Candy - Journal of Neuroscience, 2017 - Soc Neuroscience
… Here we show that the TARP γ-2 (stargazin) is present in SDH neurons and is necessary in
a form of inflammatory pain-induced plasticity, which involves an increase in the prevalence …
a form of inflammatory pain-induced plasticity, which involves an increase in the prevalence …