TARP redundancy is critical for maintaining AMPA receptor function

K Menuz, JL O'Brien, S Karmizadegan… - Journal of …, 2008 - Soc Neuroscience
Transmembrane AMPA receptor regulatory proteins (TARPs) are AMPA receptor auxiliary
subunits that influence diverse aspects of receptor function. However, the full complement of …

LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes

N Sheng, MA Bemben, J Díaz-Alonso… - Proceedings of the …, 2018 - National Acad Sciences
… Long-term potentiation (LTP) is a persistent strengthening of synaptic transmission in the
brain and is arguably the most compelling cellular and molecular model for learning and …

Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors

J Schwenk, N Harmel, G Zolles, W Bildl, A Kulik… - Science, 2009 - science.org
Glutamate receptors of the AMPA-subtype (AMPARs), together with the transmembrane
AMPAR regulatory proteins (TARPs), mediate fast excitatory synaptic transmission in the …

Stargazin promotes closure of the AMPA receptor ligand-binding domain

DM MacLean, SS Ramaswamy, M Du… - Journal of General …, 2014 - rupress.org
… where τ is the time constant for inhibition from Eq. 1 for a given concentration of NBQX… is
the forward rate constant for binding in M −1 s −1 , and k off is the rate constant for unbinding in s

[HTML][HTML] … of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA) receptor subunit GluA2 from the endoplasmic reticulum is stimulated by a complex …

W Lu, L Khatri, EB Ziff - Journal of Biological Chemistry, 2014 - ASBMB
… We show that upon Ca 2+ release from the ER via the IP3 and ryanodine receptors, CaMKII
that is activated enters a complex that contains PICK1, dependent upon the PICK1 BAR (Bin-…

The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits

C Straub, S Tomita - Current opinion in neurobiology, 2012 - Elsevier
At excitatory synapses in the brain, glutamate released from nerve terminals binds to
glutamate receptors to mediate signaling between neurons. Glutamate receptors expressed in …

Expression and Development of TARP γ-4 in Embryonic Zebrafish

KT Ahmed, MR Amin, P Razmara, B Roy… - Developmental …, 2022 - karger.com
… One such family of proteins is the transmembrane AMPAR-related proteins, known as
TARPs. Little is known about the role of TARPs during development or about their function in …

A three-step model for the synaptic recruitment of AMPA receptors

P Opazo, D Choquet - Molecular and Cellular Neuroscience, 2011 - Elsevier
The amount of AMPARs at synapses is not a fixed number but varies according to different
factors including synaptic development, activity and disease. Because the number of …

Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors

JS Martenson, S Tomita - Current opinion in pharmacology, 2015 - Elsevier
… One challenge in studying mechanisms of AMPAR synaptic localization is that the number
of AMPARs at synapses is dynamically regulated during synaptic plasticity [38]. Recent …

[HTML][HTML] TARP γ-2 is required for inflammation-associated AMPA receptor plasticity within lamina II of the spinal cord dorsal horn

SJ Sullivan, M Farrant, SG Cull-Candy - Journal of Neuroscience, 2017 - Soc Neuroscience
… Here we show that the TARP γ-2 (stargazin) is present in SDH neurons and is necessary in
a form of inflammatory pain-induced plasticity, which involves an increase in the prevalence …