Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy
TL Spires, M Meyer-Luehmann, EA Stern… - Journal of …, 2005 - Soc Neuroscience
Accumulation of amyloid-β (Aβ) into senile plaques in Alzheimer's disease (AD) is a hallmark
neuropathological feature of the disorder, which likely contributes to alterations in neuronal …
neuropathological feature of the disorder, which likely contributes to alterations in neuronal …
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
…, V Khurana, ML Steinhilb, TL Spires… - Nature cell …, 2007 - nature.com
Hyperphosphorylated forms of the microtubule-associated protein (MAP) tau accumulate in
Alzheimer's disease and related tauopathies and are thought to have an important role in …
Alzheimer's disease and related tauopathies and are thought to have an important role in …
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy
TL Spires, JD Orne, K SantaCruz, R Pitstick… - The American journal of …, 2006 - Elsevier
Neurofibrillary tangles form in a specific spatial and temporal pattern in Alzheimer's disease.
Although tangle formation correlates with dementia and neuronal loss, it remains unknown …
Although tangle formation correlates with dementia and neuronal loss, it remains unknown …
Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
TL Spires, HE Grote, NK Varshney… - Journal of …, 2004 - Soc Neuroscience
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by a CAG
repeat expansion encoding an extended polyglutamine tract in the huntingtin protein. …
repeat expansion encoding an extended polyglutamine tract in the huntingtin protein. …
Transgenic models of Alzheimer's disease: learning from animals
As the scope of the problem of Alzheimer's disease (AD) grows due to an aging population,
research into the devastating condition has taken on added urgency. Rare inherited forms of …
research into the devastating condition has taken on added urgency. Rare inherited forms of …
Dendritic spine pathology and deficits in experience‐dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice
TL Spires, HE Grote, S Garry… - European Journal of …, 2004 - Wiley Online Library
Huntington's disease (HD) is a fatal neurodegenerative disease caused by a CAG repeat
expansion coding for an expanded polyglutamine tract in the huntingtin protein. Dendritic …
expansion coding for an expanded polyglutamine tract in the huntingtin protein. Dendritic …
[HTML][HTML] Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's …
A Van Dellen, PM Cordery, TL Spires, C Blakemore… - BMC neuroscience, 2008 - Springer
Background Huntington's disease (HD) is a neurodegenerative disorder predominantly affecting
the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat …
the cerebral cortex and striatum. Transgenic mice (R6/1 line), expressing a CAG repeat …
Neuronal structure is altered by amyloid plaques
During the course of Alzheimer's disease (AD), neurons undergo extensive remodeling,
contributing to the loss of function observed in the disease. Many brain regions in patients with …
contributing to the loss of function observed in the disease. Many brain regions in patients with …
Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease: FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th …
… diameter of protein aggregates in the cortex, as visualized by using electron microscopy [50]
and light microscopy (TL Spires, JH Cha and AJ Hannan, unpublished observation). …
and light microscopy (TL Spires, JH Cha and AJ Hannan, unpublished observation). …
Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-β1 signalling
The phospholipase C-β1 (PLC-β1) signalling pathway, activated via metabotropic glutamate
receptors (mGluRs), is implicated in activity-dependent development of the cerebral cortex, …
receptors (mGluRs), is implicated in activity-dependent development of the cerebral cortex, …