We present an extensive assessment of mutation burden through sequencing analysis of >81,000
tumors from pediatric and adult patients, including tumors with hypermutation caused …

Purpose: T-cell dysfunction is a hallmark of glioblastoma (GBM). Although anergy and
tolerance have been well characterized, T-cell exhaustion remains relatively unexplored. …

Background: Glioblastoma multiforme is a malignant intracranial neoplasm that constitutes a
therapeutic challenge because of the associated high morbidity and mortality given the lack …

… TM Johanns and CA Miller contributed equally to this article. … Training Program at Washington
University School of Medicine (TM Johanns), and an endowment to The Elizabeth H. and …

Malignant gliomas are the most common primary brain cancer diagnosed and still carry a
poor prognosis despite aggressive multimodal management. Despite the continued advances …

Neoantigens are tumor-specific peptide sequences resulting from sources such as somatic
DNA mutations. Upon loading onto major histocompatibility complex (MHC) molecules, they …

The pathogenesis of persistent infection is dictated by the balance between opposing immune
activation and suppression signals. Herein, virulent Salmonella was used to explore the …

Glioblastoma (GBM) remains a disease with a poor prognosis. Unfortunately, over the past
decade, no new treatment options have improved survival in patients beyond the current …

… TM Johanns and JP Ward contributed equally to this article. … ), and the Physician-Scientist
Training Program at Washington University School of Medicine(TM Johanns and JP Ward). …

This study describes the impact of spatial heterogeneity on genomic and immunologic
characteristics of gliomas and brain metastases. The results suggest that gliomas harbor …