User profiles for T. W. Vanderah

Todd Vanderah

Professor and Chair of Pharmacology, University of Arizona
Verified email at email.arizona.edu
Cited by 19334

Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin

TW Vanderah, MH Ossipov, J Lai, TP Malan Jr… - Pain, 2001 - Elsevier
… Such opioid-induced abnormal pain was also demonstrated with repeated daily removal
and concurrent replacement of subcutaneous morphine pellets (Vanderah and Porreca, …

Peripheral mechanisms of pain and analgesia

…, MR Vasko, GL Wilcox, AC Overland, TW Vanderah… - Brain research …, 2009 - Elsevier
This review summarizes recent findings on peripheral mechanisms underlying the generation
and inhibition of pain. The focus is on events occurring in peripheral injured tissues that …

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

…, J Lai, T King, TW Vanderah… - … Original Research on …, 2005 - Wiley Online Library
The opioid analgesics, commonly exemplified by morphine, represent the best option for the
treatment of severe pain and for the management of chronic pain states, of both malignant …

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

…, A Makriyannis, TW Vanderah… - Proceedings of the …, 2005 - National Acad Sciences
CB 2 cannabinoid receptor-selective agonists are promising candidates for the treatment of
pain. CB 2 receptor activation inhibits acute, inflammatory, and neuropathic pain responses …

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

…, J Kwan, HP Mata, TW Vanderah… - Proceedings of the …, 2003 - National Acad Sciences
We designed AM1241, a selective CB 2 cannabinoid receptor agonist, and used it to test
the hypothesis that CB 2 receptor activation would reverse the sensory hypersensitivity …

Unmasking the tonic-aversive state in neuropathic pain

…, L Vera-Portocarrero, T Gutierrez, TW Vanderah… - Nature …, 2009 - nature.com
Tonic pain has been difficult to demonstrate in animals. Because relief of pain is rewarding,
analgesic agents that are not rewarding in the absence of pain should become rewarding …

[HTML][HTML] Molecular determinants of vanilloid sensitivity in TRPV1

…, A Toth, LV Pearce, TW Vanderah… - Journal of biological …, 2004 - ASBMB
Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the
pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia …

AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2, 3-dihydrobenzo [b][1, 4] dioxin-6-yl) acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic …

…, D Immke, J Wang, D Zhu, TW Vanderah… - … of Pharmacology and …, 2005 - ASPET
The vanilloid receptor 1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel
expressed by peripheral sensory neurons. TRPV1 antagonists produce antihyperalgesic …

Distinct potassium channels on pain-sensing neurons

MN Rasband, EW Park, TW Vanderah… - Proceedings of the …, 2001 - National Acad Sciences
Differential expression of ion channels contributes functional diversity to sensory neuron
signaling. We find nerve injury induced by the Chung model of neuropathic pain leads to …

Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance

TW Vanderah, LR Gardell, SE Burgess… - Journal of …, 2000 - Soc Neuroscience
… (TW Vanderah and F. Porreca, unpublished observations). Furthermore, peripheral nerve
injury also results in a decrease in μ-opioid receptor expression, supporting the possibility of …