The human apolipoprotein (apo) E gene is polymorphic, with three common alleles (epsilon
2, epsilon 3, epsilon 4) coding for three isoforms (E2, E3, E4). The isoforms differ from each …

Alzheimer's disease (AD) is a major public health concern due to longer life expectancy in
the Western countries. Amyloid-beta (Aβ) oligomers are considered the proximate effectors in …

… NS, not significantly different, *P<0.05, **P<0.01 determined by one-sample t-test versus …
P<0.05, ***P<0.001 determined by one-sample t-test versus hypothetical value of 100%. …

… Differences between control and treated groups were analyzed using Student's t test (**P <
… Differences between control and treated groups were analyzed using Student's t test (**P < …

Despite an exponential production of data, Alzheimer's disease (AD) remains an enigma.
Unresolved questions persist in the face of the heterogeneity of this neuropathology. Recent …

… Differences between groups were tested with unpaired t test, one-way analysis of variance
(ANOVA) followed by Bonferroni multiple comparison, two-way ANOVA or two-way repeated …

A growing body of evidence supports the notion that soluble oligomers of amyloid‐β (Aβ)
peptide interact with the neuronal plasma membrane, leading to cell injury and inducing death‐…

The development of novel therapeutic strategies for Alzheimer's disease (AD) represents
one of the biggest unmet medical needs today. Application of neurotrophic factors able to …

Recent data have revealed that soluble oligomeric forms of amyloid peptide (Aβ) may be
the proximate effectors of the neuronal injury and death occurring in Alzheimer's disease (AD). …

A growing body of evidence supports the notion that soluble oligomeric forms of the amyloid
β-peptide (Aβ) may be the proximate effectors of neuronal injuries and death in the early …