Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing

TL Yaksh - Pharmacology Biochemistry and Behavior, 1985 - Elsevier
… Thus, Yaksh demonstrated that in primates rendered tolerant to intrathecal morphine there
was no loss of response to the intrathecally administered ST-91 (but see [52]). We have thus …

Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques

TL Yaksh, TA Rudy - Pain, 1977 - journals.lww.com
… It is interesting to note that Pert and Yaksh [186] have described experiments where … the
tip of the injector cannula became peripheral to t,he peduncles and not after injections were …

Spinal opiate analgesia: characteristics and principles of action

TL Yaksh - Pain, 1981 - journals.lww.com
… Surh t’i’wts on the mpl: t medialtvi by populations of large diameter afferents are largely …
with the rr;: ion mos: scnsiti\-r to ihr, &~ t’riph;~;~ l stilrnlus being the last to disappear Pinch …

Quantitative assessment of tactile allodynia in the rat paw

…, FW Bach, JW Pogrel, JM Chung, TL Yaksh - Journal of neuroscience …, 1994 - Elsevier
We applied and validated a quantitative allodynia assessment technique, using a recently
developed rat surgical neuropathy model wherein nocifensive behaviors are evoked by light …

Chronic catheterization of the spinal subarachnoid space

TL Yaksh, TA Rudy - Physiology & behavior, 1976 - Elsevier
… ance to the repeated application of narcotics (Yaksh and Kohl, unpublished experiments), …
The catheter tip rests in the vicinity of T-12 at the rostral face of the lumbar cord enlargement…

Analgesia mediated by a direct spinal action of narcotics

TL Yaksh, TA Rudy - Science, 1976 - science.org
… By flexing the head downward and continually rotating the catheter during insertion, the
incidence of damage to spinal tissue was limited to one or two rats in ten (T. L. Yaksh and TA …

Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo

TL Yaksh, TM Jessell, R Gamse, AW Mudge… - Nature, 1980 - nature.com
The central terminals of small diameter primary sensory neurones associated with the
transmission of noxious cutaneous stimuli are located predominantly in the superficial dorsal horn …

Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition

AB Malmberg, TL Yaksh - Science, 1992 - science.org
… rats (280 to 320 g) were implanted under halothane (2%) anesthesia with lumbar polyethylene
(PE-1 0) IT catheters according to a modified method originally described by TL Yaksh

Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat.

AB Malmberg, TL Yaksh - Journal of Pharmacology and Experimental …, 1992 - ASPET
Subcutaneous injection of formalin into the dorsal surface of the hindpaw evoked a two-phased
flinching (phase 1:0-9 min; phase 2: 10-60 min) of the injected paw. Intrathecal …

Upregulation of dorsal root ganglion α2δ calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats

…, KA Stauderman, ME Williams, TL Yaksh - Journal of …, 2001 - Soc Neuroscience
T/A cloning was performed by exploiting the single 3′ adenosine overhang generated in …
-T), the monoclonal or polyclonal antibodies were used to probe the membranes in PBS-T for …