G-protein–coupled receptors (GPCRs) constitute the largest family of receptors and major
pharmacological targets. Whereas many GPCRs have been shown to form di-/oligomers, the …

IKB is an inhibitory protein that stabilizes the inducible cytoplasmic form of the NF-KB transcription
factor. We have purified lKB-a, a major form of IKB with an apparent molecular size of …

Background Corticotropin-independent Cushing's syndrome is caused by tumors or
hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal …

… U). It is therefore possible that chloroquine either did not intercalate in the KB site, or, that
NF-KB was able to displace DNA-intercalated chloroquine. We consider it less likely that NF-…

We show that the non-DNA-binding precursor for the~ 50 subunit (pl lo), like NF-KB, is subject
to control of nuclear uptake. In contrast to~ 50,~ 110 was excluded from nuclei and unable …

… Rabbit reticulocyte lysates (Promega) were programmed with the respective mRNAs in
the presence of 40 U RNase inhibitor (Boehringer) and 50-100 itCi [35S]L-methionine (Amersham…

… The Mann–Whitney U test was used as post-hoc test to identify where the stochastic
dominance occurs or for how many pairs of groups stochastic dominance is obtained. …

Cells relay a plethora of extracellular signals to specific cellular responses by using only a
few second messengers, such as cAMP. To explain signaling specificity, cAMP-degrading …

Endothelial dysfunction, as observed in hypertension and atherosclerosis, is associated
with a reduction in the bioavailability of endothelium-derived nitric oxide (NO). We tested the …

Functional evidence suggests that nitric oxide released from CA1 pyramidal cells can act as
a retrograde messenger to mediate hippocampal long-term potentiation, but the failure to …