Molecular Genetics of Neuronal Recognition in Drosophila: Evolution and Function of Immunoglobulin Superfamily Cell Adhesion Molecules
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Excerpt
One form of neuronal recognition is the remarkable selectivity shown by neuronal growth cones in their ability to recognize and extend along specific axonal surfaces, a process called selective fasciculation. At the Cold Spring Harbor Symposium on Molecular Neurobiology in 1983, Raper, Bastiani, and Goodman (1983c) proposed on the basis of a long series of descriptive and experimental studies on the mechanisms of selective fasciculation in the grasshopper (Raper et al. 1983 a,b, 1984; Bastiani et al. 1984) that neighboring axon pathways must be differentially labeled by surface recognition molecules, which allow growth cones to distinguish among them—a notion they called the labeled pathways hypothesis. Subsequent cellular analysis from our laboratory in both the grasshopper (Bastiani et al. 1986; Doe et al. 1986; du Lac et al. 1986) and a simple vertebrate (the fish spinal cord; see Kuwada 1986) further supported this hypothesis. At about the same time, other studies...
