Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis
- Yasutaka Niwa1,2,3,
- Hiromi Shimojo1,2,
- Akihiro Isomura1,2,
- Aitor González1,2,
- Hitoshi Miyachi1 and
- Ryoichiro Kageyama1,2,4
- 1Institute for Virus Research, Kyoto University, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan;
- 2Japan Science and Technology Agency, CREST, Shogoin-Kawahara, Sakyo-ku, Kyoto 606-8507, Japan
Abstract
Somitogenesis is controlled by cyclic genes such as Notch effectors and by the wave front established by morphogens such as Fgf8, but the precise mechanism of how these factors are coordinated remains to be determined. Here, we show that effectors of Notch and Fgf pathways oscillate in different dynamics and that oscillations in Notch signaling generate alternating phase shift, thereby periodically segregating a group of synchronized cells, whereas oscillations in Fgf signaling released these synchronized cells for somitogenesis at the same time. These results suggest that Notch oscillators define the prospective somite region, while Fgf oscillators regulate the pace of segmentation.
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Footnotes
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↵4 Corresponding author.
E-MAIL rkageyam{at}virus.kyoto-u.ac.jp; FAX 81-75-751-4807.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.2035311.
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Supplemental material is available for this article.
- Received January 23, 2011.
- Accepted April 21, 2011.
- Copyright © 2011 by Cold Spring Harbor Laboratory Press
Freely available online through the Genes & Development Open Access option.