Optimization of visual training for full recovery from severe amblyopia in adults
- 1Department of Biology, University of Maryland, College Park, Maryland 20742, USA
- 2Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, Maryland 20742, USA
- Corresponding author: equinlan{at}umd.edu
Abstract
The severe amblyopia induced by chronic monocular deprivation is highly resistant to reversal in adulthood. Here we use a rodent model to show that recovery from deprivation amblyopia can be achieved in adults by a two-step sequence, involving enhancement of synaptic plasticity in the visual cortex by dark exposure followed immediately by visual training. The perceptual learning induced by visual training contributes to the recovery of vision and can be optimized to drive full recovery of visual acuity in severely amblyopic adults.
Footnotes
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Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.040295.115.
- Received September 22, 2015.
- Accepted December 1, 2015.
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