Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory
- 1Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
- 2Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Abstract
Long-term memory formation involves covalent modification of the histone proteins that package DNA. Reducing histone acetylation by mutating histone acetyltransferases impairs long-term memory, and enhancing histone acetylation by inhibiting histone deacetylases (HDACs) improves long-term memory. Previous studies using HDAC inhibitors to enhance long-term memory have focused on the fear-conditioning task using broad-spectrum HDAC inhibitors. We have found that post-training intrahippocampal administration of the broad-spectrum HDAC inhibitor trichostatin A (TSA) or the class I HDAC-selective inhibitor MS275 enhances long-term object-location memory, supporting a role for class I HDACs in the enhancement of hippocampus-dependent memory induced by HDAC inhibition.
Footnotes
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↵3 Corresponding author.
E-mail abele{at}sas.upenn.edu; fax (215) 898-8780.
- Received December 2, 2010.
- Accepted March 13, 2011.
- © 2011 Cold Spring Harbor Laboratory Press
