Insular cortex is involved in consolidation of object recognition memory
- Federico Bermudez-Rattoni1,2,4,
- Shoki Okuda1,3,
- Benno Roozendaal1, and
- James L. McGaugh1
- 1Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697-3800, USA2 Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F., 04510, México3 CNS Disorder Research, Tsukuba Research Institute, Banyu Pharmaceutical Co., Tsukuba, Ibaraki, 300-2611, Japan
This extract was created in the absence of an abstract.
Previous findings indicate that the insular cortex (IC) is involved in conditioned taste aversion and taste recognition. Here we report evidence that the IC is not uniquely dedicated to taste learning but plays a more general role in consolidating recognition memories. Immediate post-training infusions of the muscarinic cholinergic receptor antagonist scopolamine administered into the IC produced locus-specific and time-dependent impairment of object recognition memory.
Extensive evidence indicates that the IC, also termed gustatory cortex, is critically involved in conditioned taste aversion and taste recognition memory (Bermudez-Rattoni 2004). Although most studies of the involvement of the IC in memory have investigated taste, there is some evidence that the IC is involved in memory that is not based on taste (Bermudez-Rattoni and McGaugh 1991; Bermudez-Rattoni et al. 1991; Paller et al. 2003; Reed et al. 2004). Converging evidence from animal and human studies suggests that a network of temporal cortical …
