The image shows pan-neuronal transgenic expression of the wild-type palmitoyltransferase SPTL-1 (red), a protein that catalyzes the first step in sphingolipid biosynthesis, in a C. elegans sptl-1 mutant. The expression in neurons rescues the intestinal polarity defect (apical membrane labeled in green), suggesting that SPTL-1 acts cell non-autonomously, probably because sphinganine, the immediate product of SPTL-1, can move freely between cells. For more information, see the article by Cui et al. (pages 5816–5834).