Confocal image of neuromuscular junctions (NMJs) from a pre-symptomatic mouse model of amyotrophic lateral sclerosis (ALS). Fluorescently tagged α-bungarotoxin (green) shows postsynaptic acetylcholine receptors. Immunolabeling of neurofilament and synaptic vesicle protein-2 (magenta) highlights motor nerve axons and synaptic terminals. This mouse model points to degeneration of outer motor nerve axons of the NMJ as an early rising ALS sign. See the article by Kathryn R. Moss et al. for more information on how aging and disease target the NMJ. Cover image: Yomna Badawi.