This image shows the morphology of mouse glia 24 hours after four serial systemic injections of endotoxin. Circumventricular organs were immunostained for microglia/macrophages (Iba1, red), astrocytes (GFAP, green) and nuclei (DRAQ5, blue). Serial systemic endotoxin injections elicit neuroprotective spinal cord microglia through interleukin-1-dependent cross-talk with endothelial cells. For more information, see the article by Freria et al. (pages 9103–9120). Cover Image: Faith H. Brennan.