Pictured is blood oxygenation consumption, a MRI measure for brain activation, in different parts of the brain related to changes in inhibitory signaling (light blue) and the inhibitory—excitatory balance (dark blue) from the inferior parietal cortex during a cognitive flexibility task. Geraldine Rodriguez-Nieto and colleagues observed that older adults had increased oxygen consumption associated to a decreased inhibition during task performance. At the same time, an increased inhibitory tone favored flexible performance in the same sample, whereas the opposite pattern was observed in younger adults. See the article by Rodriguez-Nieto et al. for more information on age-related differences in inhibitory and excitatory signaling that contribute to cognitive skill execution. Cover image: Geraldine Rodriguez-Nieto.