This image shows the expression of the potassium, chloride co-transporter KCC2 (red), the peptide CGRP (blue), the non-peptidergic neuronal marker IB4 (green), and the neuronal marker NeuN (white) in the spinal dorsal horn of a female mouse. CGRP promotes pain phenotypes in female, but not male mice, through a mechanism that involves elevation of the GABA reversal potential but not quantifiable changes in the expression level of KCC2 at the neuronal plasma membrane. For more information, see the article by Paige et al. (pages 1930–1944). Cover image: Melina Papalampropoulou-Tsiridou using protocol developed by Louis-Etienne Lorenzo in the laboratory of Yves De Koninck.