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Current Issue Table of Contents: 3 Dec 2025 Volume 45, Issue 49

The Journal of Neuroscience: 45 (49)

About the Cover

Shown is a coronal brain section from a mouse with neurons visible via Golgi staining. This mouse received an injection of a virus containing an inhibitor of neural stem cell division (sFRP3) into the hippocampus. Because seizures during Alzheimer's disease disrupt hippocampal neuron production and potentially contribute to cognitive decline by lowering sFRP3 expression, this approach was used to assess whether restoring sFRP3 levels combats these symptoms. See the article by Chia-Hsuan Fu et al. for more information about the mechanism they identified that may explain the link between seizures and cognitive decline in Alzheimer's disease. Cover image: Chia-Hsuan Fu.

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