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Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neurons

MA Hynes, M Gitt, SH Barondes, TM Jessell and LB Buck
Journal of Neuroscience 1 March 1990, 10 (3) 1004-1013; DOI: https://doi.org/10.1523/JNEUROSCI.10-03-01004.1990
MA Hynes
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032.
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M Gitt
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032.
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SH Barondes
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032.
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TM Jessell
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032.
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LB Buck
Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032.
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Abstract

Cellular interactions in a variety of vertebrate non-neural tissues are thought to be mediated by cell surface carbohydrate structures. The detection of cell-specific surface carbohydrates and carbohydrate- binding proteins within the embryonic nervous system has raised the possibility that carbohydrate recognition may also contribute to the interactions of developing neurons. Soluble lactose-binding lectins constitute one class of carbohydrate-binding proteins expressed in the vertebrate nervous system. We describe here the isolation of cDNAs from rat brain libraries encoding one of these lectins, RL-14.5, and demonstrate that this protein is not only homologous to other soluble lectins, but also identical in primary sequence to a lectin present in at least one non-neural tissue. RNA blot analysis and in situ hybridization reveal a restricted pattern of expression of RL-14.5 mRNA within the rat nervous system. High levels of RL-14.5 mRNA are present in primary sensory neurons and motoneurons in the spinal cord and brain stem. Moreover, expression of RL-14.5 mRNA in sensory and motoneurons is detectable soon after neuronal differentiation. These findings, together with previous studies demonstrating the selective expression of oligosaccharide ligands for RL-14.5 on the same neurons, are consistent with the idea that carbohydrate-mediated interactions contribute to the development of this subset of mammalian neurons.

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The Journal of Neuroscience: 10 (3)
Journal of Neuroscience
Vol. 10, Issue 3
1 Mar 1990
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Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neurons
MA Hynes, M Gitt, SH Barondes, TM Jessell, LB Buck
Journal of Neuroscience 1 March 1990, 10 (3) 1004-1013; DOI: 10.1523/JNEUROSCI.10-03-01004.1990

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Selective expression of an endogenous lactose-binding lectin gene in subsets of central and peripheral neurons
MA Hynes, M Gitt, SH Barondes, TM Jessell, LB Buck
Journal of Neuroscience 1 March 1990, 10 (3) 1004-1013; DOI: 10.1523/JNEUROSCI.10-03-01004.1990
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