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Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP

E Palombo, LJ Porrino, KS Bankiewicz, AM Crane, L Sokoloff and IJ Kopin
Journal of Neuroscience 1 March 1990, 10 (3) 860-869; DOI: https://doi.org/10.1523/JNEUROSCI.10-03-00860.1990
E Palombo
Laboratory of Cerebral Metabolism, National Institute on Mental Health, Bethesda, Maryland 20892.
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LJ Porrino
Laboratory of Cerebral Metabolism, National Institute on Mental Health, Bethesda, Maryland 20892.
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KS Bankiewicz
Laboratory of Cerebral Metabolism, National Institute on Mental Health, Bethesda, Maryland 20892.
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AM Crane
Laboratory of Cerebral Metabolism, National Institute on Mental Health, Bethesda, Maryland 20892.
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L Sokoloff
Laboratory of Cerebral Metabolism, National Institute on Mental Health, Bethesda, Maryland 20892.
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IJ Kopin
Laboratory of Cerebral Metabolism, National Institute on Mental Health, Bethesda, Maryland 20892.
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Abstract

Quantitative 2-[14C]deoxyglucose autoradiography was used to map the pattern of alterations in local cerebral glucose utilization associated with unilateral lesions of the substantia nigra pars compacta produced by the infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into one internal carotid artery of rhesus monkeys. These monkeys become hemiparkinsonian, displaying rigidity, bradykinesia, and tremor of the limbs contralateral to the side of MPTP infusion; during spontaneous activity they turn toward the side of the lesion. Eighty- two brain areas were examined, and statistically significant metabolic changes were confined mainly to basal ganglia structures ipsilateral to the side of the lesion. Glucose utilization was reduced in the substantia nigra pars compacta and ventral tegmental area, i.e., in the areas of cell loss. Increases in glucose utilization in regions normally innervated by the lesioned area were observed in the post- commissural portions of the putamen and dorsolateral caudate. Other structures showing statistically significant metabolic changes were the external segment of the globus pallidus (+40%), subthalamic nucleus (- 17%), and pedunculopontine nucleus (+15%). There were also smaller changes in portions of the thalamus (ventral anterior nucleus, parafascicular nucleus) and premotor cortex. All significant metabolic changes were confined to the side of the substantia nigra lesion and were essentially restricted to regions involved in the production of movement or maintenance of posture.

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The Journal of Neuroscience: 10 (3)
Journal of Neuroscience
Vol. 10, Issue 3
1 Mar 1990
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Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP
E Palombo, LJ Porrino, KS Bankiewicz, AM Crane, L Sokoloff, IJ Kopin
Journal of Neuroscience 1 March 1990, 10 (3) 860-869; DOI: 10.1523/JNEUROSCI.10-03-00860.1990

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Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP
E Palombo, LJ Porrino, KS Bankiewicz, AM Crane, L Sokoloff, IJ Kopin
Journal of Neuroscience 1 March 1990, 10 (3) 860-869; DOI: 10.1523/JNEUROSCI.10-03-00860.1990
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