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Cyclic GMP levels and guanylate cyclase activity in pheromone-sensitive antennae of the silkmoths Antheraea polyphemus and Bombyx mori

G Ziegelberger, MJ van den Berg, KE Kaissling, S Klumpp and JE Schultz
Journal of Neuroscience 1 April 1990, 10 (4) 1217-1225; https://doi.org/10.1523/JNEUROSCI.10-04-01217.1990
G Ziegelberger
Max-Planck-Institut fur Verhaltensphysiologie, Seewiesen, Federal Republic of Germany.
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MJ van den Berg
Max-Planck-Institut fur Verhaltensphysiologie, Seewiesen, Federal Republic of Germany.
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KE Kaissling
Max-Planck-Institut fur Verhaltensphysiologie, Seewiesen, Federal Republic of Germany.
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S Klumpp
Max-Planck-Institut fur Verhaltensphysiologie, Seewiesen, Federal Republic of Germany.
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JE Schultz
Max-Planck-Institut fur Verhaltensphysiologie, Seewiesen, Federal Republic of Germany.
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Abstract

Female sex pheromones applied to freshly isolated, living antennae of male Antheraea polyphemus and Bombyx mori led to an increase of cGMP. A 1:1 mixture of 2 pheromone components of Antheraea polyphemus blown for 10 sec in physiological concentrations over their antennal branches raised cGMP levels about 1.34-fold (+/- 0.08 SEM, n = 23) from a basal level of 3.0 +/- 0.6 (SEM, n = 20) pmol/mg protein. Similarly, bombykol elicited a 1.29-fold (+/- 0.13 SEM, n = 23) cGMP increase in antennae of male Bombyx mori from a basal level of 2.7 +/- 0.5 (SEM, n = 24) pmol/mg protein. No cross-sensitivity was found with respect to pheromones from either species. In antennae of female silkmoths, the cGMP response was missing upon stimulation with their own respective pheromones according to the known lack of pheromone receptor cells in the female. cAMP levels in the male antennae of 14.2 +/- 2.9 (SEM, n = 4) pmol/mg protein in A. polyphemus and 15.0 +/- 3.0 (SEM, n = 5) pmol/mg protein in B. mori were not affected by pheromone stimulation. Within 1–60 sec, the extent of cGMP increase in B. mori was independent of the duration of pheromone exposure. The levels of cGMP in pheromone- stimulated antennae of both species remained elevated for at least 10 min, i.e., much longer than the duration of the receptor potential measured in single-cell recordings. Guanylate cyclase activity was identified in homogenates of male and female antennae from both species. The Km of the guanylate cyclase from male B. mori for the preferential substrate MnGTP was 175 microM.(ABSTRACT TRUNCATED AT 250 WORDS)

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The Journal of Neuroscience: 10 (4)
Journal of Neuroscience
Vol. 10, Issue 4
1 Apr 1990
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Cyclic GMP levels and guanylate cyclase activity in pheromone-sensitive antennae of the silkmoths Antheraea polyphemus and Bombyx mori
G Ziegelberger, MJ van den Berg, KE Kaissling, S Klumpp, JE Schultz
Journal of Neuroscience 1 April 1990, 10 (4) 1217-1225; DOI: 10.1523/JNEUROSCI.10-04-01217.1990

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Cyclic GMP levels and guanylate cyclase activity in pheromone-sensitive antennae of the silkmoths Antheraea polyphemus and Bombyx mori
G Ziegelberger, MJ van den Berg, KE Kaissling, S Klumpp, JE Schultz
Journal of Neuroscience 1 April 1990, 10 (4) 1217-1225; DOI: 10.1523/JNEUROSCI.10-04-01217.1990
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