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Articles

Distinct patterns of expression of two VAMP genes within the rat brain

WS Trimble, TS Gray, LA Elferink, MC Wilson and RH Scheller
Journal of Neuroscience 1 April 1990, 10 (4) 1380-1387; DOI: https://doi.org/10.1523/JNEUROSCI.10-04-01380.1990
WS Trimble
Department of Biological Sciences, Stanford University, California 94305.
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TS Gray
Department of Biological Sciences, Stanford University, California 94305.
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LA Elferink
Department of Biological Sciences, Stanford University, California 94305.
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MC Wilson
Department of Biological Sciences, Stanford University, California 94305.
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RH Scheller
Department of Biological Sciences, Stanford University, California 94305.
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Abstract

VAMPs are synaptic vesicle-specific proteins composed of a carboxy- terminal hydrophobic membrane anchor and an approximately 100 amino acid domain oriented towards the cytoplasm. In rat, two 77% homologous VAMP genes are expressed in the CNS. To precisely localize the neurons expressing these 2 forms of VAMP, we have used RNA blotting and in situ hybridization histochemistry with RNA probes specific for the 3′ untranslated regions of the transcripts. These experiments revealed that the 2 genes are expressed in distict, but slightly overlapping, patterns in the rat brain. VAMP-1 expression is localized to a limited number of nuclei, particularly those involved in modulating somatomotor functions, while VAMP-2 expression is more ubiquitous, being found in nuclei associated with autonomic, sensory, and integrative roles. These data suggest that the specific structural features of individual VAMPs may play an important role in synaptic vesicle metabolism.

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The Journal of Neuroscience: 10 (4)
Journal of Neuroscience
Vol. 10, Issue 4
1 Apr 1990
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Distinct patterns of expression of two VAMP genes within the rat brain
WS Trimble, TS Gray, LA Elferink, MC Wilson, RH Scheller
Journal of Neuroscience 1 April 1990, 10 (4) 1380-1387; DOI: 10.1523/JNEUROSCI.10-04-01380.1990

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Distinct patterns of expression of two VAMP genes within the rat brain
WS Trimble, TS Gray, LA Elferink, MC Wilson, RH Scheller
Journal of Neuroscience 1 April 1990, 10 (4) 1380-1387; DOI: 10.1523/JNEUROSCI.10-04-01380.1990
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