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Acetylcholine release from the rabbit retina mediated by kainate receptors

DM Linn, C Blazynski, DA Redburn and SC Massey
Journal of Neuroscience 1 January 1991, 11 (1) 111-122; DOI: https://doi.org/10.1523/JNEUROSCI.11-01-00111.1991
DM Linn
Sensory Sciences Center, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston 77030.
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C Blazynski
Sensory Sciences Center, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston 77030.
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DA Redburn
Sensory Sciences Center, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston 77030.
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SC Massey
Sensory Sciences Center, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston 77030.
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Abstract

The cholinergic amacrine cells of the rabbit retina may be labeled with 3H-choline (3H-Ch), and the activity of the cholinergic population may be monitored by following the release of 3H-ACh. Glutamate analogs caused massive ACh release, up to 50 times the basal efflux, with the following rank order of potency: alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) greater than quisqualate (QQ) = kainate (KA) much greater than NMDA (in magnesium-free medium) much greater than glutamate greater than aspartate. In contrast, the release of 3H- Ch was unchanged. Submaximal doses of each agonist were used to establish the specifity of glutamate antagonists. Kynurenic acid was selective for KA much greater than QQ, and 6,7-dinitroquinoxaline-2,3- dione (DNQX) was selective for KA greater than QQ much greater than NMDA. At low doses, which selectively blocked the response to KA, both antagonists blocked the light-evoked release of ACh. These results suggest that ACh release may be produced via several glutamate receptors, but the physiological input to the cholinergic amacrine cells is mediated by KA receptors. Because these cells receive direct input from cone bipolar cells, this work supports previous evidence that the bipolar cell transmitter is glutamate.

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The Journal of Neuroscience: 11 (1)
Journal of Neuroscience
Vol. 11, Issue 1
1 Jan 1991
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Acetylcholine release from the rabbit retina mediated by kainate receptors
DM Linn, C Blazynski, DA Redburn, SC Massey
Journal of Neuroscience 1 January 1991, 11 (1) 111-122; DOI: 10.1523/JNEUROSCI.11-01-00111.1991

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Acetylcholine release from the rabbit retina mediated by kainate receptors
DM Linn, C Blazynski, DA Redburn, SC Massey
Journal of Neuroscience 1 January 1991, 11 (1) 111-122; DOI: 10.1523/JNEUROSCI.11-01-00111.1991
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