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Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease

G Perry, SL Siedlak, P Richey, M Kawai, P Cras, RN Kalaria, PG Galloway, JM Scardina, B Cordell and BD Greenberg
Journal of Neuroscience 1 November 1991, 11 (11) 3679-3683; DOI: https://doi.org/10.1523/JNEUROSCI.11-11-03679.1991
G Perry
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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SL Siedlak
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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P Richey
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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M Kawai
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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P Cras
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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RN Kalaria
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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PG Galloway
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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JM Scardina
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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B Cordell
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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BD Greenberg
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
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Abstract

The major intracytoplasmic lesion of Alzheimer's disease is the neurofibrillary tangle (NFT), which is primarily composed of paired helical filaments (PHFs). The mechanism responsible for the formation of PHFs, as well as their insolubility and apparent heterogeneity, is unknown. We found that basic fibroblast growth factor (bFGF) binds to heparinase-sensitive sites in NFTs. bFGF binding is due to a heparan sulfate proteoglycan (HSPG) immunocytochemically identified in NFTs. In the presence of polycations (e.g., Ca2+), HSPG will bind to free carboxyl groups in NFT proteins. HSPG binding may play a role in transforming normal soluble proteins into insoluble PHFs.

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The Journal of Neuroscience: 11 (11)
Journal of Neuroscience
Vol. 11, Issue 11
1 Nov 1991
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Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease
G Perry, SL Siedlak, P Richey, M Kawai, P Cras, RN Kalaria, PG Galloway, JM Scardina, B Cordell, BD Greenberg
Journal of Neuroscience 1 November 1991, 11 (11) 3679-3683; DOI: 10.1523/JNEUROSCI.11-11-03679.1991

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Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease
G Perry, SL Siedlak, P Richey, M Kawai, P Cras, RN Kalaria, PG Galloway, JM Scardina, B Cordell, BD Greenberg
Journal of Neuroscience 1 November 1991, 11 (11) 3679-3683; DOI: 10.1523/JNEUROSCI.11-11-03679.1991
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