Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

M Herkenham; AB Lynn; MR Johnson; LS Melvin; BR de Costa; KC Rice

doi:10.1523/JNEUROSCI.11-02-00563.1991

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.11-02-00563.1991

PubMed

1992016

Published By

Society for Neuroscience

History

First published February 1, 1991.

Version of record published February 1, 1991.

Author Information

M Herkenham,
AB Lynn,
MR Johnson,
LS Melvin,
BR de Costa, and
KC Rice

Section on Functional Neuroanatomy, National Institute of Mental Health, Bethesda, Maryland 20892.

Author contributions

Disclosures

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	Abstract	Full	Pdf
Jan 1999	2	0	0
Feb 1999	2	0	0
Mar 1999	6	0	0
Dec 1999	2	0	0
Total 1999	12	0	0
Jan 2000	2	0	0
Mar 2000	4	0	0
Apr 2000	5	0	0
May 2000	5	0	0
Jun 2000	3	0	0
Jul 2000	2	0	0
Aug 2000	3	0	0
Sep 2000	8	0	0
Oct 2000	5	0	0
Nov 2000	7	0	0
Dec 2000	2	0	0
Total 2000	46	0	0
Jan 2001	3	0	0
Feb 2001	7	0	0
Mar 2001	2	0	0
Apr 2001	7	0	0
May 2001	7	0	0
Jun 2001	9	0	0
Jul 2001	7	0	0
Aug 2001	7	0	0
Sep 2001	4	0	0
Oct 2001	11	0	0
Nov 2001	9	0	0
Dec 2001	1	0	0
Total 2001	74	0	0
Jan 2002	6	0	0
Feb 2002	8	0	0
Mar 2002	9	0	0
Apr 2002	12	0	0
May 2002	8	0	0
Jun 2002	5	0	0
Jul 2002	6	0	0
Aug 2002	4	0	0
Sep 2002	10	0	0
Oct 2002	9	0	0
Nov 2002	3	0	0
Dec 2002	6	0	0
Total 2002	86	0	0
Jan 2003	8	0	0
Feb 2003	5	0	0
Mar 2003	10	0	0
Apr 2003	10	0	0
May 2003	17	0	0
Jun 2003	4	0	0
Jul 2003	12	0	0
Aug 2003	9	0	0
Sep 2003	15	0	0
Oct 2003	23	0	0
Nov 2003	18	0	22
Dec 2003	16	0	3
Total 2003	147	0	25
Jan 2004	14	0	24
Feb 2004	10	0	27
Mar 2004	19	0	24
Apr 2004	19	0	21
May 2004	22	0	57
Jun 2004	15	0	58
Jul 2004	13	0	21
Aug 2004	27	0	38
Sep 2004	7	0	20
Oct 2004	23	0	48
Nov 2004	17	0	43
Dec 2004	33	0	31
Total 2004	219	0	412
Jan 2005	47	0	40
Feb 2005	28	0	80
Mar 2005	41	0	132
Apr 2005	23	1	81
May 2005	13	0	41
Jun 2005	18	0	63
Jul 2005	8	0	29
Aug 2005	22	0	89
Sep 2005	22	0	40
Oct 2005	30	0	61
Nov 2005	34	0	75
Dec 2005	12	0	34
Total 2005	298	1	765
Jan 2006	13	0	82
Feb 2006	26	0	58
Mar 2006	31	0	76
Apr 2006	21	0	61
May 2006	16	0	67
Jun 2006	15	0	43
Jul 2006	3	0	26
Aug 2006	7	0	28
Sep 2006	15	0	48
Oct 2006	13	0	36
Nov 2006	28	0	66
Dec 2006	17	0	38
Total 2006	205	0	629
Jan 2007	14	0	55
Feb 2007	13	0	42
Mar 2007	29	0	71
Apr 2007	28	0	60
May 2007	15	0	81
Jun 2007	13	0	59
Jul 2007	18	0	56
Aug 2007	17	0	65
Sep 2007	20	0	59
Oct 2007	26	0	77
Nov 2007	16	0	38
Dec 2007	15	0	58
Total 2007	224	0	721
Jan 2008	28	0	68
Feb 2008	34	0	68
Mar 2008	41	0	75
Apr 2008	40	0	84
May 2008	23	0	73
Jun 2008	27	0	48
Jul 2008	21	0	58
Aug 2008	29	0	39
Sep 2008	29	0	75
Oct 2008	37	0	59
Nov 2008	35	0	68
Dec 2008	21	0	42
Total 2008	365	0	757
Jan 2009	25	0	98
Feb 2009	45	0	88
Mar 2009	47	0	102
Apr 2009	64	0	173
May 2009	32	0	104
Jun 2009	24	0	76
Jul 2009	22	0	62
Aug 2009	23	0	55
Sep 2009	41	0	57
Oct 2009	34	0	74
Nov 2009	40	0	100
Dec 2009	38	0	74
Total 2009	435	0	1063
Jan 2010	47	0	64
Feb 2010	32	0	79
Mar 2010	59	0	102
Apr 2010	61	0	104
May 2010	62	0	84
Jun 2010	29	0	73
Jul 2010	39	0	59
Aug 2010	39	0	51
Sep 2010	33	0	67
Oct 2010	42	0	54
Nov 2010	50	0	61
Dec 2010	46	0	66
Total 2010	539	0	864
Jan 2011	61	0	82
Feb 2011	45	0	76
Mar 2011	78	0	73
Apr 2011	55	0	83
May 2011	70	1	52
Jun 2011	43	0	43
Jul 2011	60	0	51
Aug 2011	49	0	41
Sep 2011	52	0	52
Oct 2011	120	1	117
Nov 2011	81	1	80
Dec 2011	45	2	47
Total 2011	759	5	797
Jan 2012	45	0	62
Feb 2012	39	0	47
Mar 2012	53	0	68
Apr 2012	37	1	63
May 2012	61	0	52
Jun 2012	44	0	40
Jul 2012	39	0	44
Aug 2012	30	0	38
Sep 2012	55	0	61
Oct 2012	41	0	56
Nov 2012	77	0	68
Dec 2012	54	0	36
Total 2012	575	1	635
Jan 2013	50	0	47
Feb 2013	39	0	45
Mar 2013	62	0	45
Apr 2013	49	0	45
May 2013	46	0	61
Jun 2013	34	0	39
Jul 2013	43	0	51
Aug 2013	22	0	27
Sep 2013	26	0	30
Oct 2013	57	0	52
Nov 2013	61	1	68
Dec 2013	27	0	30
Total 2013	516	1	540
Jan 2014	47	0	53
Feb 2014	45	0	32
Mar 2014	117	0	50
Apr 2014	131	0	44
May 2014	85	0	51
Jun 2014	69	0	32
Jul 2014	65	0	45
Aug 2014	40	0	28
Sep 2014	81	0	50
Oct 2014	50	1	46
Nov 2014	79	0	83
Dec 2014	69	0	59
Total 2014	878	1	573
Jan 2015	69	1	51
Feb 2015	80	2	88
Mar 2015	111	0	70
Apr 2015	87	3	47
May 2015	82	0	65
Jun 2015	88	0	60
Jul 2015	33	0	37
Aug 2015	46	0	51
Sep 2015	61	0	46
Oct 2015	69	0	69
Nov 2015	63	0	74
Dec 2015	67	0	121
Total 2015	856	6	779
Jan 2016	68	0	62
Feb 2016	77	1	60
Mar 2016	89	4	103
Apr 2016	96	0	98
May 2016	84	1	91
Jun 2016	60	0	77
Jul 2016	45	2	65
Aug 2016	65	3	39
Sep 2016	68	5	67
Oct 2016	107	0	112
Nov 2016	118	0	125
Dec 2016	107	0	60
Total 2016	984	16	959
Jan 2017	107	0	51
Feb 2017	76	0	28
Mar 2017	112	0	45
Apr 2017	70	0	40
May 2017	120	0	54
Jun 2017	43	0	25
Jul 2017	42	0	20
Aug 2017	41	0	28
Sep 2017	45	0	25
Oct 2017	63	0	57
Nov 2017	116	0	85
Dec 2017	66	0	49
Total 2017	901	0	507
Jan 2018	74	0	63
Feb 2018	74	0	48
Mar 2018	84	0	70
Apr 2018	85	0	76
May 2018	59	0	45
Jun 2018	53	0	45
Jul 2018	57	0	46
Aug 2018	66	0	38
Sep 2018	76	0	46
Oct 2018	85	0	63
Nov 2018	114	0	75
Dec 2018	57	0	47
Total 2018	884	0	662
Jan 2019	78	0	55
Feb 2019	91	0	54
Mar 2019	79	0	45
Apr 2019	80	0	57
May 2019	77	0	43
Jun 2019	66	0	60
Jul 2019	76	0	44
Aug 2019	82	0	43
Sep 2019	71	0	32
Oct 2019	126	0	50
Nov 2019	89	0	55
Dec 2019	73	0	38
Total 2019	988	0	576
Jan 2020	73	0	19
Feb 2020	69	0	41
Mar 2020	96	0	53
Apr 2020	59	0	38
May 2020	65	0	37
Jun 2020	53	0	42
Jul 2020	55	0	50
Aug 2020	43	0	54
Sep 2020	88	0	59
Oct 2020	58	0	67
Nov 2020	93	0	52
Dec 2020	71	0	23
Total 2020	823	0	535
Jan 2021	130	0	43
Feb 2021	122	0	67
Mar 2021	110	0	66
Apr 2021	79	0	121
May 2021	103	0	66
Jun 2021	98	0	37
Jul 2021	64	0	57
Aug 2021	116	0	52
Sep 2021	78	0	56
Oct 2021	114	0	93
Nov 2021	77	0	64
Dec 2021	90	0	62
Total 2021	1181	0	784
Jan 2022	84	0	71
Feb 2022	82	0	57
Mar 2022	62	0	72
Apr 2022	92	0	78
May 2022	72	0	59
Jun 2022	46	0	28
Total 2022	438	0	365
Total	12433	31	12948