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A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons

L Plessers, JA Eggermont, F Wuytack and R Casteels
Journal of Neuroscience 1 March 1991, 11 (3) 650-656; DOI: https://doi.org/10.1523/JNEUROSCI.11-03-00650.1991
L Plessers
Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholicke Universiteit Leuven, Belgium.
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JA Eggermont
Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholicke Universiteit Leuven, Belgium.
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F Wuytack
Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholicke Universiteit Leuven, Belgium.
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R Casteels
Laboratorium voor Fysiologie, Campus Gasthuisberg, Katholicke Universiteit Leuven, Belgium.
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Abstract

Pig cerebellar Purkinje neurons express a high level of Ca2(+)- transport ATPases in their intracellular Ca2+ stores. This was shown at the mRNA level by Northern blotting and in situ hybridization and at the protein level by Western blotting and immunocytochemistry. The majority of the Ca2(+)-transport ATPases in these neurons belongs to the SERCA2b type (i.e., the Ca2(+)-pump isoform found in most nonmuscle cells). The SERCA2a (cardiac/slow-twitch skeletal/smooth muscle) Ca2(+)- pump isoform is expressed only at very low levels. The main Ca2(+)-pump messenger is 6.0 kilobases long and belongs to a class 4-type processing of SERCA2, which is exclusively confined to the cerebrum and cerebellum. Phospholamban, a regulator of the SERCA2 Ca2(+)-transport ATPase in cardiac/slow-twitch skeletal/smooth muscle, could not be detected in Purkinje neurons.

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The Journal of Neuroscience: 11 (3)
Journal of Neuroscience
Vol. 11, Issue 3
1 Mar 1991
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A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons
L Plessers, JA Eggermont, F Wuytack, R Casteels
Journal of Neuroscience 1 March 1991, 11 (3) 650-656; DOI: 10.1523/JNEUROSCI.11-03-00650.1991

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A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons
L Plessers, JA Eggermont, F Wuytack, R Casteels
Journal of Neuroscience 1 March 1991, 11 (3) 650-656; DOI: 10.1523/JNEUROSCI.11-03-00650.1991
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