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Interaction of colocalized neuropeptides: functional significance in the circadian timing system

HE Albers, SY Liou, EG Stopa and RT Zoeller
Journal of Neuroscience 1 March 1991, 11 (3) 846-851; DOI: https://doi.org/10.1523/JNEUROSCI.11-03-00846.1991
HE Albers
Department of Biology, Georgia State University, Atlanta 30303.
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SY Liou
Department of Biology, Georgia State University, Atlanta 30303.
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EG Stopa
Department of Biology, Georgia State University, Atlanta 30303.
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RT Zoeller
Department of Biology, Georgia State University, Atlanta 30303.
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Abstract

The suprachiasmatic nucleus (SCN), which appears to act as a circadian clock, contains a subpopulation of local circuit neurons in which vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI), and gastrin releasing peptide (GRP) are colocalized. To determine whether VIP, PHI, and GRP interact within the SCN to produce a signal important for circadian control, the behavioral and cellular effects of coadministration of these neuropeptides were investigated. Coadministration of VIP, PHI, and GRP within the SCN mimicked the phase- delaying effects of light on circadian control following in vivo microinjection and activated SCN single units recorded in vitro. These behavioral and cellular effects of coadministration of VIP, PHI, and GRP were significantly greater than administration of VIP, PHI, or GRP alone or coadministration of any 2 of these peptides. These data illustrate a new mechanism whereby multiple, colocalized neuropeptides interact in a functionally significant manner, and indicate that the interaction of VIP, PHI, and GRP may be involved in the regulation of circadian rhythms by the SCN.

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The Journal of Neuroscience: 11 (3)
Journal of Neuroscience
Vol. 11, Issue 3
1 Mar 1991
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Interaction of colocalized neuropeptides: functional significance in the circadian timing system
HE Albers, SY Liou, EG Stopa, RT Zoeller
Journal of Neuroscience 1 March 1991, 11 (3) 846-851; DOI: 10.1523/JNEUROSCI.11-03-00846.1991

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Interaction of colocalized neuropeptides: functional significance in the circadian timing system
HE Albers, SY Liou, EG Stopa, RT Zoeller
Journal of Neuroscience 1 March 1991, 11 (3) 846-851; DOI: 10.1523/JNEUROSCI.11-03-00846.1991
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