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Learning-dependent neuronal activity in the premotor cortex: activity during the acquisition of conditional motor associations

AR Mitz, M Godschalk and SP Wise
Journal of Neuroscience 1 June 1991, 11 (6) 1855-1872; DOI: https://doi.org/10.1523/JNEUROSCI.11-06-01855.1991
AR Mitz
Laboratory of Neurophysiology, National Institute of Mental Health, Poolesville, Maryland 20837.
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M Godschalk
Laboratory of Neurophysiology, National Institute of Mental Health, Poolesville, Maryland 20837.
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SP Wise
Laboratory of Neurophysiology, National Institute of Mental Health, Poolesville, Maryland 20837.
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Abstract

It has been proposed that the premotor cortex plays a role in the selection of motor programs based on environmental context. To test this hypothesis, we recorded the activity of single neurons as monkeys learned visuomotor associations. The hypothesis predicts that task- related premotor cortical activity before learning should differ from that afterward. We found that a substantial population of premotor cortex neurons, over half of those adequately tested, showed the predicted learning-dependent changes in activity. The present findings support a role for premotor cortex in motor preparation, generally, and suggest a specific role in the selection of movements on the basis of arbitrary associations.

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The Journal of Neuroscience: 11 (6)
Journal of Neuroscience
Vol. 11, Issue 6
1 Jun 1991
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Learning-dependent neuronal activity in the premotor cortex: activity during the acquisition of conditional motor associations
AR Mitz, M Godschalk, SP Wise
Journal of Neuroscience 1 June 1991, 11 (6) 1855-1872; DOI: 10.1523/JNEUROSCI.11-06-01855.1991

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Learning-dependent neuronal activity in the premotor cortex: activity during the acquisition of conditional motor associations
AR Mitz, M Godschalk, SP Wise
Journal of Neuroscience 1 June 1991, 11 (6) 1855-1872; DOI: 10.1523/JNEUROSCI.11-06-01855.1991
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