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Selectivity of the effects of guanosine-5'-O-(2-thiodiphosphate) on agonist inhibition of the M-current in amphibian sympathetic neurons

MA Simmons and RJ Mather
Journal of Neuroscience 1 July 1991, 11 (7) 2130-2134; https://doi.org/10.1523/JNEUROSCI.11-07-02130.1991
MA Simmons
Department of Pharmacology, Marshall University, Huntington, West Virginia 25755–9310.
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RJ Mather
Department of Pharmacology, Marshall University, Huntington, West Virginia 25755–9310.
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Abstract

In bullfrog sympathetic neurons, luteinizing hormone-releasing hormone, muscarine, and substance P act as agonists at specific membrane receptors to decrease a potassium current, IM. The receptors are coupled to guanine nucleotide-binding proteins (G-proteins). Whole-cell recordings of IM were made from isolated bullfrog sympathetic neurons to examine the effects of intracellularly applied guanosine-5′-O-(2- thiodiphosphate) (GDP beta S) on agonist inhibition of IM. Successive responses to a given agonist were decreased in the presence of GDP beta s. Subsequent responses to the other agonists were then measured to determine the degree of overlap of the effect of GDP beta S for the different agonists. GDP beta S selectively inhibited successive responses to one agonist such that a subsequent application of a different agonist was still effective. If GDP beta S acts at the level of the G-protein, this suggests that each receptor is coupled to a separate population of G-proteins. Alternatively, GDP beta S may act at the receptor level to block receptor coupling to IM.

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The Journal of Neuroscience: 11 (7)
Journal of Neuroscience
Vol. 11, Issue 7
1 Jul 1991
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Selectivity of the effects of guanosine-5'-O-(2-thiodiphosphate) on agonist inhibition of the M-current in amphibian sympathetic neurons
MA Simmons, RJ Mather
Journal of Neuroscience 1 July 1991, 11 (7) 2130-2134; DOI: 10.1523/JNEUROSCI.11-07-02130.1991

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Selectivity of the effects of guanosine-5'-O-(2-thiodiphosphate) on agonist inhibition of the M-current in amphibian sympathetic neurons
MA Simmons, RJ Mather
Journal of Neuroscience 1 July 1991, 11 (7) 2130-2134; DOI: 10.1523/JNEUROSCI.11-07-02130.1991
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