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Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium

TM Esterle and E Sanders-Bush
Journal of Neuroscience 1 December 1992, 12 (12) 4775-4782; DOI: https://doi.org/10.1523/JNEUROSCI.12-12-04775.1992
TM Esterle
Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232.
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E Sanders-Bush
Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232.
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Abstract

Choroid plexus epithelial cells are enriched in mRNA for proteins such as the iron carrier transferrin, which acts as a trophic factor in the brain. Choroid plexus epithelial cells also have a high density of 5- HT1C receptors linked to activation of the phosphoinositide (PI) hydrolysis second messenger system. The present studies show that the 5- HT1C/5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2- aminopropane (DOI) potently increases PI hydrolysis and the levels of transferrin in primary cultures of rat choroid plexus epithelial cells. These effects are blocked by the 5-HT1C/5-HT2 receptor antagonists mesulergine and mianserin, but not by the 5-HT2 receptor-selective antagonist spiperone. Similarly, mesulergine and mianserin, but not spiperone, block the increases in transferrin levels and PI hydrolysis elicited by 5-carboxamidotryptamine (5-CT), a 5-HT1 receptor-selective agonist, and by serotonin. We conclude, therefore, that 5-HT1C receptor activation in the choroid plexus leads to an increase in the production of transferrin. By promoting transferrin synthesis in the choroid plexus, 5-HT may indirectly influence brain development and differentiation.

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The Journal of Neuroscience: 12 (12)
Journal of Neuroscience
Vol. 12, Issue 12
1 Dec 1992
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Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium
TM Esterle, E Sanders-Bush
Journal of Neuroscience 1 December 1992, 12 (12) 4775-4782; DOI: 10.1523/JNEUROSCI.12-12-04775.1992

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Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium
TM Esterle, E Sanders-Bush
Journal of Neuroscience 1 December 1992, 12 (12) 4775-4782; DOI: 10.1523/JNEUROSCI.12-12-04775.1992
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