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Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans

CM Loer and CJ Kenyon
Journal of Neuroscience 1 December 1993, 13 (12) 5407-5417; DOI: https://doi.org/10.1523/JNEUROSCI.13-12-05407.1993
CM Loer
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
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CJ Kenyon
Department of Biochemistry and Biophysics, University of California, San Francisco 94143.
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Abstract

Defining a behavior that requires the function of specific neurons in the free-living nematode Caenorhabditis elegans can allow one to screen for mutations that disrupt the specification or function of those neurons. We identified serotonin-immunoreactive neurons required for tail curling or “turning” behavior exhibited by C. elegans males during mating. Males mutant in three different genes that reduce serotonin expression, cat-1, cat-4, and bas-1, exhibited defects in turning behavior similar to those of wild-type males in which these neurons were ablated. The turning defect of cat-4 males was rescued by exogenous serotonin, consistent with the idea that their behavioral defect is caused by a lack of serotonin. While the serotonin-deficient mutants we analyzed shared certain behavioral traits, they were blocked for serotonin synthesis at different steps. Analysis of these and additional serotonin-deficient mutants may help us understand how a neuron controls the expression of a serotonergic phenotype.

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The Journal of Neuroscience: 13 (12)
Journal of Neuroscience
Vol. 13, Issue 12
1 Dec 1993
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Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
CM Loer, CJ Kenyon
Journal of Neuroscience 1 December 1993, 13 (12) 5407-5417; DOI: 10.1523/JNEUROSCI.13-12-05407.1993

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Serotonin-deficient mutants and male mating behavior in the nematode Caenorhabditis elegans
CM Loer, CJ Kenyon
Journal of Neuroscience 1 December 1993, 13 (12) 5407-5417; DOI: 10.1523/JNEUROSCI.13-12-05407.1993
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