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Coexpression of mRNAs for NGF, BDNF, and NT-3 in the cardiovascular system of the pre- and postnatal rat

IA Scarisbrick, EG Jones and PJ Isackson
Journal of Neuroscience 1 March 1993, 13 (3) 875-893; https://doi.org/10.1523/JNEUROSCI.13-03-00875.1993
IA Scarisbrick
Department of Anatomy, University of California, Irvine 92717.
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EG Jones
Department of Anatomy, University of California, Irvine 92717.
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PJ Isackson
Department of Anatomy, University of California, Irvine 92717.
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Abstract

The expression of NGF, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) mRNAs was examined in whole rat embryos and in the heart and great vessels of postnatal and adult rats, using in situ hybridization of cRNA probes. The patterns of expression were correlated with innervation patterns as revealed by immunostaining for neural cell adhesion molecule (NCAM) and with the HNK-1 antibody, which demonstrates derivatives of the neural crest. The patterns of neurotrophin mRNA localization were different from those of mRNAs for the low-molecular-weight NGF receptor. Hybridization indicating the presence of mRNAs for all three neurotrophins is particularly prominent within the tunica media of the aorta, pulmonary, and other major elastic arteries of the thorax and abdomen and is first observed on embryonic day 13 (E13) when innervation is being established and rises to maximum by E15. In the fetus, there is little or no detectable expression in the CNS or PNS. NT-3 expression in the vessels is relatively constant and high from embryonic to adult stages, while levels of BDNF increase and those of NGF decrease over the same time course. During the fetal period, hybridization in the heart is absent. In the postnatal period, additional label becomes detectable in the coronary arteries but not in the walls of the atria or ventricles, other than at the base of the aorta and pulmonary trunk.(ABSTRACT TRUNCATED AT 250 WORDS)

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The Journal of Neuroscience: 13 (3)
Journal of Neuroscience
Vol. 13, Issue 3
1 Mar 1993
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Coexpression of mRNAs for NGF, BDNF, and NT-3 in the cardiovascular system of the pre- and postnatal rat
IA Scarisbrick, EG Jones, PJ Isackson
Journal of Neuroscience 1 March 1993, 13 (3) 875-893; DOI: 10.1523/JNEUROSCI.13-03-00875.1993

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Coexpression of mRNAs for NGF, BDNF, and NT-3 in the cardiovascular system of the pre- and postnatal rat
IA Scarisbrick, EG Jones, PJ Isackson
Journal of Neuroscience 1 March 1993, 13 (3) 875-893; DOI: 10.1523/JNEUROSCI.13-03-00875.1993
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