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Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression

DT Chalmers, SP Kwak, A Mansour, H Akil and SJ Watson
Journal of Neuroscience 1 March 1993, 13 (3) 914-923; https://doi.org/10.1523/JNEUROSCI.13-03-00914.1993
DT Chalmers
Mental Health Research Institute, University of Michigan, Ann Arbor 48109.
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SP Kwak
Mental Health Research Institute, University of Michigan, Ann Arbor 48109.
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A Mansour
Mental Health Research Institute, University of Michigan, Ann Arbor 48109.
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H Akil
Mental Health Research Institute, University of Michigan, Ann Arbor 48109.
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SJ Watson
Mental Health Research Institute, University of Michigan, Ann Arbor 48109.
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Abstract

Using in situ hybridization techniques, the expression of 5-HT1A receptor mRNA was measured within the hippocampal formation after bilateral adrenalectomy (ADX). After 24 hr ADX, 5-HT1A receptor mRNA expression was significantly increased in all hippocampal subfields in ADX animals relative to sham-operated controls (SHAM). The magnitude of the increase was most pronounced within CA2 (127%) and CA3/4 (94%)- subfields of dorsal hippocampus, intermediate in the dentate gyrus (73%), and least within CA1 (60%). Administration of exogenous corticosterone (CORT) at the time of ADX maintained the level of 5-HT1A receptor mRNA expression within the range of SHAM animals. In vitro receptor autoradiographic analysis of 5-HT1A receptors in adjacent sections from the same animals indicated a simultaneous increase in 5- HT1A binding throughout the hippocampus in response to ADX. 5-HT1A binding increased to a similar extent (approximately 30%) in CA subfields and dentate gyrus but remained within SHAM levels in CORT- replaced animals. 5-HT1A receptor mRNA levels were also increased in hippocampal subregions of 1 week ADX animals relative to SHAM animals. Within both CA1 and CA2 subfields, the increments were approximately double those observed after 1 d ADX. 5-HT1A receptor binding was increased in every hippocampal subfield to a similar extent as that observed after 1 d ADX. Increases in both 5-HT1A receptor mRNA expression and 5-HT1A receptor binding were preventable by administration of exogenous CORT at the time of ADX. Hippocampal 5-HT1C receptor mRNA and D1 receptor mRNA expression were not significantly altered by either acute or chronic ADX treatment. These data indicate that adrenal steroids may selectively regulate hippocampal 5-HT1A receptors at the level of 5-HT1A receptor mRNA expression.

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The Journal of Neuroscience: 13 (3)
Journal of Neuroscience
Vol. 13, Issue 3
1 Mar 1993
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Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression
DT Chalmers, SP Kwak, A Mansour, H Akil, SJ Watson
Journal of Neuroscience 1 March 1993, 13 (3) 914-923; DOI: 10.1523/JNEUROSCI.13-03-00914.1993

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Corticosteroids regulate brain hippocampal 5-HT1A receptor mRNA expression
DT Chalmers, SP Kwak, A Mansour, H Akil, SJ Watson
Journal of Neuroscience 1 March 1993, 13 (3) 914-923; DOI: 10.1523/JNEUROSCI.13-03-00914.1993
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