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The buccalin-related neuropeptides: isolation and characterization of an Aplysia cDNA clone encoding a family of peptide cotransmitters

MW Miller, S Beushausen, EC Cropper, K Eisinger, S Stamm, FS Vilim, A Vitek, A Zajc, I Kupfermann and J Brosius
Journal of Neuroscience 1 August 1993, 13 (8) 3346-3357; DOI: https://doi.org/10.1523/JNEUROSCI.13-08-03346.1993
MW Miller
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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S Beushausen
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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EC Cropper
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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K Eisinger
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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S Stamm
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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FS Vilim
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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A Vitek
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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A Zajc
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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I Kupfermann
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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J Brosius
Center for Neurobiology and Behavior, New York State Psychiatric Institute, New York 10032.
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Abstract

The buccalin-related peptides, buccalin A and buccalin B, are members of a family of cotransmitters that modulate neuromuscular transmission in Aplysia. In this study, a third buccalin-related peptide, buccalin C, was purified from neuronal elements in the accessory radula closer, a muscle involved in the animal's feeding behavior. Oligonucleotide probes based upon the amino acid sequence of buccalin C were used to isolate cDNA clones that encode a buccalin precursor polypeptide. The buccalin precursor contains 19 distinct buccalin-related peptides, several of which are present in multiple copies. The buccalin gene appears to be present in a single copy, with one allele containing a small insert. Expression of this gene occurs in a tissue-specific manner and mRNA transcripts are abundant within neurons in the Aplysia CNS. This large family of neuropeptides may exert extraordinarily complex modulatory actions at synapses where they serve as cotransmitters.

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The Journal of Neuroscience: 13 (8)
Journal of Neuroscience
Vol. 13, Issue 8
1 Aug 1993
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The buccalin-related neuropeptides: isolation and characterization of an Aplysia cDNA clone encoding a family of peptide cotransmitters
MW Miller, S Beushausen, EC Cropper, K Eisinger, S Stamm, FS Vilim, A Vitek, A Zajc, I Kupfermann, J Brosius
Journal of Neuroscience 1 August 1993, 13 (8) 3346-3357; DOI: 10.1523/JNEUROSCI.13-08-03346.1993

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The buccalin-related neuropeptides: isolation and characterization of an Aplysia cDNA clone encoding a family of peptide cotransmitters
MW Miller, S Beushausen, EC Cropper, K Eisinger, S Stamm, FS Vilim, A Vitek, A Zajc, I Kupfermann, J Brosius
Journal of Neuroscience 1 August 1993, 13 (8) 3346-3357; DOI: 10.1523/JNEUROSCI.13-08-03346.1993
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