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Articles

The S cell: an interneuron essential for sensitization and full dishabituation of leech shortening

CL Sahley, BK Modney, NM Boulis and KJ Muller
Journal of Neuroscience 1 November 1994, 14 (11) 6715-6721; DOI: https://doi.org/10.1523/JNEUROSCI.14-11-06715.1994
CL Sahley
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.
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BK Modney
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.
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NM Boulis
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.
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KJ Muller
Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.
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Abstract

Sensory neurons in the leech excite the S interneuron, which in turn excites motoneurons that shorten the leech, although activity in the S cell reportedly cannot by itself shorten the animal. Experiments were performed in semi-intact leeches using established dishabituation and sensitization protocols. S-cell activity increased during reflexive shortening once the animal was sensitized or dishabituated with a strong shock. S-cell activity otherwise was not associated with shortening. To test the role of the S-cell in dishabituation and sensitization of the shortening reflex, single S cells were ablated in vivo by intracellular injections of pronase. S-cell lesions reduced but did not eliminate dishabituation; however, sensitization was completely disrupted. This was consistent with recent evidence that separate processes contribute to dishabituation and sensitization. Since the S cell in each ganglion is a link in a rapidly conducting chain along the length of the animal, it may be sufficient to break the chain at a single point to eliminate sensitization.

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The Journal of Neuroscience: 14 (11)
Journal of Neuroscience
Vol. 14, Issue 11
1 Nov 1994
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The S cell: an interneuron essential for sensitization and full dishabituation of leech shortening
CL Sahley, BK Modney, NM Boulis, KJ Muller
Journal of Neuroscience 1 November 1994, 14 (11) 6715-6721; DOI: 10.1523/JNEUROSCI.14-11-06715.1994

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The S cell: an interneuron essential for sensitization and full dishabituation of leech shortening
CL Sahley, BK Modney, NM Boulis, KJ Muller
Journal of Neuroscience 1 November 1994, 14 (11) 6715-6721; DOI: 10.1523/JNEUROSCI.14-11-06715.1994
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