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Articles

Dual effects of angiotensin II on calcium currents in neonatal rat nodose neurons

K Bacal and DL Kunze
Journal of Neuroscience 1 November 1994, 14 (11) 7159-7167; DOI: https://doi.org/10.1523/JNEUROSCI.14-11-07159.1994
K Bacal
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030.
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DL Kunze
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030.
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Abstract

Angiotensin II (AII) reversibly modulates calcium current in isolated neonatal rat nodose ganglion cells by two different pathways. A maximum inhibitory effect of 43 +/- 6% (n = 25) of the peak calcium current at - 10 mV was observed at 10 nM AII. The IC50 of the inhibitory response was 100 pM. Losartan, a specific antagonist for the AT1 type of AII receptor, abolished the AII-induced inhibition, as did preincubation with pertussis toxin (PTX). When omega-conotoxin GVIA (CTX) was added to the bath solution, AII produced no inhibition of the remaining calcium current, indicating that the AII inhibition was mediated through CTX-sensitive calcium channels. Reversible facilitation of calcium current was seen more rarely. The AII-induced facilitation was unaffected by losartan and PTX, indicating that the effect is mediated by a non-AT1 receptor and does not depend upon a PTX-sensitive G- protein. The facilitation is present when the CTX-sensitive current has been blocked and involves activation of a reserve pool of dihydropyridine (DHP)-sensitive channels. In general, a particular neuron exhibited either inhibition or facilitation. However, in some neurons both inhibition and facilitation could be demonstrated in the presence of the appropriate blocking agents.

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The Journal of Neuroscience: 14 (11)
Journal of Neuroscience
Vol. 14, Issue 11
1 Nov 1994
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Dual effects of angiotensin II on calcium currents in neonatal rat nodose neurons
K Bacal, DL Kunze
Journal of Neuroscience 1 November 1994, 14 (11) 7159-7167; DOI: 10.1523/JNEUROSCI.14-11-07159.1994

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Dual effects of angiotensin II on calcium currents in neonatal rat nodose neurons
K Bacal, DL Kunze
Journal of Neuroscience 1 November 1994, 14 (11) 7159-7167; DOI: 10.1523/JNEUROSCI.14-11-07159.1994
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