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Enhancement of voltage-gated Ca2+ currents induced by daily stimulation of hippocampal neurons with glutamate

DE Garcia, A Cavalie and HD Lux
Journal of Neuroscience 1 February 1994, 14 (2) 545-553; DOI: https://doi.org/10.1523/JNEUROSCI.14-02-00545.1994
DE Garcia
Department of Neurophysiology, Max-Planck-Institut fur Psychiatrie, Martinsried, Germany.
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A Cavalie
Department of Neurophysiology, Max-Planck-Institut fur Psychiatrie, Martinsried, Germany.
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HD Lux
Department of Neurophysiology, Max-Planck-Institut fur Psychiatrie, Martinsried, Germany.
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Abstract

The regulation of calcium channel currents (ICa) induced by daily stimulation (1 hr) with 10 microM glutamate was studied in full differentiated hippocampal cells in culture. We report a specific enhancement of the high-voltage-activated current type (HVA ICa) ongoing over days. The density of HVA ICa increased about twofold after the second glutamate session, and this enhancement was still observed after the fifth day of treatment, while low-voltage-activated calcium currents (LVA ICa) remained unchanged. During glutamate application, a transient increase of intracellular calcium (Cai) was observed, followed by a slow decay within 2–3 min, and substantial recovery in about 10 min. Similarly, Cai transients induced by periodic membrane depolarization mimicked the long-term effect of glutamate on ICa. These results demonstrate for the first time an increase of ICa in a time frame of days. Since the effect of glutamate on ICa was prevented by cycloheximide, neosynthesis of channel proteins presumably supports this enhancement.

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The Journal of Neuroscience: 14 (2)
Journal of Neuroscience
Vol. 14, Issue 2
1 Feb 1994
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Enhancement of voltage-gated Ca2+ currents induced by daily stimulation of hippocampal neurons with glutamate
DE Garcia, A Cavalie, HD Lux
Journal of Neuroscience 1 February 1994, 14 (2) 545-553; DOI: 10.1523/JNEUROSCI.14-02-00545.1994

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Enhancement of voltage-gated Ca2+ currents induced by daily stimulation of hippocampal neurons with glutamate
DE Garcia, A Cavalie, HD Lux
Journal of Neuroscience 1 February 1994, 14 (2) 545-553; DOI: 10.1523/JNEUROSCI.14-02-00545.1994
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