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Articles

Relationship of APP mRNA transcripts and levels of NGF and low-affinity NGF receptors to behavioral measures of age-related cognitive dysfunction

MD Lindner, SI Dworetzky, C Sampson and R Loy
Journal of Neuroscience 1 April 1994, 14 (4) 2282-2289; DOI: https://doi.org/10.1523/JNEUROSCI.14-04-02282.1994
MD Lindner
University of Rochester School of Medicine, Monroe Community Hospital, New York 14620.
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SI Dworetzky
University of Rochester School of Medicine, Monroe Community Hospital, New York 14620.
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C Sampson
University of Rochester School of Medicine, Monroe Community Hospital, New York 14620.
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R Loy
University of Rochester School of Medicine, Monroe Community Hospital, New York 14620.
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Abstract

This study was designed to examine the relationship between cognitive function and endogenous levels of NGF, low-affinity NGF receptor (LNGFR), and amyloid precursor protein (APP) mRNAs. Using 3 month (n = 5), 18 month (n = 40), and 29 month (n = 17) Fischer-344 male rats, cognitive function was assessed with the Morris water maze, reverse transcription and polymerase chain reaction were used to quantify APP mRNAs, and NGF and LNGFR levels were determined with an ELISA. Cognitive function declined progressively with age from 3 months to 18 months, and from 18 months to 29 months, but only RNA content in the tissue declined significantly from 3 months to 18 months. Between 18 month and 29 month rats were small but statistically significant decreases only for Kunitz protease inhibitor (KPI)-inclusive mRNAs and cortical NGF levels. There was a small but statistically significant correlation between cognitive function and %KPI (the amount of KPI APP mRNAs relative to the total amount of APP mRNA), with lower %KPI related to more impaired spatial learning. No other statistically significant correlation or linear relationship could be detected between cognitive function and any of the other neurological measures or any combination of these measures (i.e., hippocampal levels of APP 695 mRNA, cortical and hippocampal levels of NGF, and cortical, hippocampal, and basal forebrain levels of LNGFR).(ABSTRACT TRUNCATED AT 250 WORDS)

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The Journal of Neuroscience: 14 (4)
Journal of Neuroscience
Vol. 14, Issue 4
1 Apr 1994
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Relationship of APP mRNA transcripts and levels of NGF and low-affinity NGF receptors to behavioral measures of age-related cognitive dysfunction
MD Lindner, SI Dworetzky, C Sampson, R Loy
Journal of Neuroscience 1 April 1994, 14 (4) 2282-2289; DOI: 10.1523/JNEUROSCI.14-04-02282.1994

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Relationship of APP mRNA transcripts and levels of NGF and low-affinity NGF receptors to behavioral measures of age-related cognitive dysfunction
MD Lindner, SI Dworetzky, C Sampson, R Loy
Journal of Neuroscience 1 April 1994, 14 (4) 2282-2289; DOI: 10.1523/JNEUROSCI.14-04-02282.1994
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