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Apoptotic cell death induced by optic nerve lesion in the neonatal rat

SA Rabacchi, L Bonfanti, XH Liu and L Maffei
Journal of Neuroscience 1 September 1994, 14 (9) 5292-5301; DOI: https://doi.org/10.1523/JNEUROSCI.14-09-05292.1994
SA Rabacchi
Scuola Normale Superiore, Pisa, Italy.
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L Bonfanti
Scuola Normale Superiore, Pisa, Italy.
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XH Liu
Scuola Normale Superiore, Pisa, Italy.
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L Maffei
Scuola Normale Superiore, Pisa, Italy.
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Abstract

Cell death can be ascribed to one of two distinct modes of degeneration: apoptosis (programmed or active cell death) or necrosis (passive degeneration). While apoptosis is generally assumed to occur in physiological conditions such as normal development or tissue turnover, necrotic cell degeneration is induced in pathological situations. Here we report that also in a pathological situation, such as after axotomy in the CNS, apoptotic type of cell death comes into play: following intracranial transection of the optic nerve in the neonatal rat in vivo, retinal ganglion cells undergo an active, apoptotic cell death. In fact, the administration of protein synthesis inhibitors (actinomycin D and cycloheximide) prevents the appearance of pyknotic nuclei as well as of fragmented DNA of ganglion cells at 24 hr postlesion. Correspondingly, the number of surviving cells after actinomycin D and cycloheximide treatment is comparable to normal, unlesioned retinas. In addition, cycloheximide decreases the number of pyknotic ganglion cells during spontaneous cell death.

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The Journal of Neuroscience: 14 (9)
Journal of Neuroscience
Vol. 14, Issue 9
1 Sep 1994
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Apoptotic cell death induced by optic nerve lesion in the neonatal rat
SA Rabacchi, L Bonfanti, XH Liu, L Maffei
Journal of Neuroscience 1 September 1994, 14 (9) 5292-5301; DOI: 10.1523/JNEUROSCI.14-09-05292.1994

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Apoptotic cell death induced by optic nerve lesion in the neonatal rat
SA Rabacchi, L Bonfanti, XH Liu, L Maffei
Journal of Neuroscience 1 September 1994, 14 (9) 5292-5301; DOI: 10.1523/JNEUROSCI.14-09-05292.1994
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