Skip to main content

Main menu

  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE

User menu

  • Log out
  • Log in
  • My Cart

Search

  • Advanced search
Journal of Neuroscience
  • Log out
  • Log in
  • My Cart
Journal of Neuroscience

Advanced Search

Submit a Manuscript
  • HOME
  • CONTENT
    • Early Release
    • Featured
    • Current Issue
    • Issue Archive
    • Collections
    • Podcast
  • ALERTS
  • FOR AUTHORS
    • Information for Authors
    • Fees
    • Journal Clubs
    • eLetters
    • Submit
  • EDITORIAL BOARD
  • ABOUT
    • Overview
    • Advertise
    • For the Media
    • Rights and Permissions
    • Privacy Policy
    • Feedback
  • SUBSCRIBE
PreviousNext
Articles

Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins

DL Shelton, J Sutherland, J Gripp, T Camerato, MP Armanini, HS Phillips, K Carroll, SD Spencer and AD Levinson
Journal of Neuroscience 1 January 1995, 15 (1) 477-491; DOI: https://doi.org/10.1523/JNEUROSCI.15-01-00477.1995
DL Shelton
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J Sutherland
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J Gripp
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T Camerato
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
MP Armanini
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
HS Phillips
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K Carroll
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
SD Spencer
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AD Levinson
Department of Neuroscience, Genentech, Inc., South San Francisco, California 94080.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • eLetters
  • PDF
Loading

Abstract

Using molecular cloning techniques, human homologs of the known members of the trk family of neurotrophin receptors have been cloned and sequenced. Overall, there is a high degree of similarity between the human sequences and those from other mammals; however, there are differences in splicing patterns. There are two spliced forms of the extracellular domain of trkC in the human, a finding that has not been described in other species. In contrast, fewer spliced forms were detected of the intracellular domains of human trkB and trkC than has been described in other mammals. Northern analysis and in situ hybridization experiments indicate that the human trks are expressed in a similar pattern to that described in other mammals. Expression of the trk extracellular domains as fusion proteins with IgG heavy chain yields soluble molecules that mimic intact trks in their binding specificity and affinity. These soluble chimeras block the biological activity of their cognate neurotrophin(s) in vitro.

Back to top

In this issue

The Journal of Neuroscience: 15 (1)
Journal of Neuroscience
Vol. 15, Issue 1
1 Jan 1995
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
Email

Thank you for sharing this Journal of Neuroscience article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
(Your Name) has forwarded a page to you from Journal of Neuroscience
(Your Name) thought you would be interested in this article in Journal of Neuroscience.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
View Full Page PDF
Citation Tools
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
DL Shelton, J Sutherland, J Gripp, T Camerato, MP Armanini, HS Phillips, K Carroll, SD Spencer, AD Levinson
Journal of Neuroscience 1 January 1995, 15 (1) 477-491; DOI: 10.1523/JNEUROSCI.15-01-00477.1995

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Respond to this article
Request Permissions
Share
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins
DL Shelton, J Sutherland, J Gripp, T Camerato, MP Armanini, HS Phillips, K Carroll, SD Spencer, AD Levinson
Journal of Neuroscience 1 January 1995, 15 (1) 477-491; DOI: 10.1523/JNEUROSCI.15-01-00477.1995
Reddit logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
  • eLetters
  • PDF

Responses to this article

Respond to this article

Jump to comment:

No eLetters have been published for this article.

Related Articles

Cited By...

More in this TOC Section

  • Choice Behavior Guided by Learned, But Not Innate, Taste Aversion Recruits the Orbitofrontal Cortex
  • Maturation of Spontaneous Firing Properties after Hearing Onset in Rat Auditory Nerve Fibers: Spontaneous Rates, Refractoriness, and Interfiber Correlations
  • Insulin Treatment Prevents Neuroinflammation and Neuronal Injury with Restored Neurobehavioral Function in Models of HIV/AIDS Neurodegeneration
Show more Articles
  • Home
  • Alerts
  • Visit Society for Neuroscience on Facebook
  • Follow Society for Neuroscience on Twitter
  • Follow Society for Neuroscience on LinkedIn
  • Visit Society for Neuroscience on Youtube
  • Follow our RSS feeds

Content

  • Early Release
  • Current Issue
  • Issue Archive
  • Collections

Information

  • For Authors
  • For Advertisers
  • For the Media
  • For Subscribers

About

  • About the Journal
  • Editorial Board
  • Privacy Policy
  • Contact
(JNeurosci logo)
(SfN logo)

Copyright © 2023 by the Society for Neuroscience.
JNeurosci Online ISSN: 1529-2401

The ideas and opinions expressed in JNeurosci do not necessarily reflect those of SfN or the JNeurosci Editorial Board. Publication of an advertisement or other product mention in JNeurosci should not be construed as an endorsement of the manufacturer’s claims. SfN does not assume any responsibility for any injury and/or damage to persons or property arising from or related to any use of any material contained in JNeurosci.