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Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain

NJ Sucher, S Akbarian, CL Chi, CL Leclerc, M Awobuluyi, DL Deitcher, MK Wu, JP Yuan, EG Jones and SA Lipton
Journal of Neuroscience 1 October 1995, 15 (10) 6509-6520; https://doi.org/10.1523/JNEUROSCI.15-10-06509.1995
NJ Sucher
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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S Akbarian
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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CL Chi
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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CL Leclerc
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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M Awobuluyi
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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DL Deitcher
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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MK Wu
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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JP Yuan
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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EG Jones
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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SA Lipton
Department of Neurology, Children's Hospital, Boston, Massachusetts, USA.
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Abstract

A novel NMDA receptor-like (NMDAR-L) cDNA was isolated that contained an open reading frame coding for a predicted polypeptide of 1115 amino acids that shares approximately 27% identity with NMDA receptor subunits. In situ hybridization experiments indicated that NMDAR-L mRNA was expressed in the developing rodent CNS. On postnatal day 1 (P1), NMDAR-L mRNA expression was pronounced in the entorhinal cortex, the subiculum and the thalamus, in layer V of the developing neocortex, in the superior and inferior colliculi, and various regions of the hindbrain, excluding the cerebellum. On P5, NMDAR-L mRNA was expressed in layer V of the neocortex, in the entorhinal cortex, in the subiculum, and in the thalamus. On P14, NMDAR-L mRNA was expressed in layers II-VI of the neocortex, in the entorhinal and piriform cortex, in the subiculum and CA1 field, and in the nucleus of the lateral olfactory tract. In the adult brain, NMDAR-L mRNA was detected predominately in the nucleus of the lateral olfactory tract. Injection of NMDAR-L cRNA into Xenopus oocytes did not lead to the expression of homomeric glutamate-activated channels. However, coinjection of the triple combination of NMDAR-L with NMDAR1 and NMDAR2B cRNAs led to a striking decrease in the current magnitude compared to currents obtained after coexpression of the double combination of NMDAR1 with NMDAR2B. While the function of NMDAR-L remains to be established, its developmental and regional expression pattern suggests that NMDAR-L may influence axonal outgrowth and synaptogenesis during brain development.

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The Journal of Neuroscience: 15 (10)
Journal of Neuroscience
Vol. 15, Issue 10
1 Oct 1995
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Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
NJ Sucher, S Akbarian, CL Chi, CL Leclerc, M Awobuluyi, DL Deitcher, MK Wu, JP Yuan, EG Jones, SA Lipton
Journal of Neuroscience 1 October 1995, 15 (10) 6509-6520; DOI: 10.1523/JNEUROSCI.15-10-06509.1995

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Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
NJ Sucher, S Akbarian, CL Chi, CL Leclerc, M Awobuluyi, DL Deitcher, MK Wu, JP Yuan, EG Jones, SA Lipton
Journal of Neuroscience 1 October 1995, 15 (10) 6509-6520; DOI: 10.1523/JNEUROSCI.15-10-06509.1995
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