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Articles

Disruption of cerebellar maturation by an antimitotic agent impairs the ontogeny of eyeblink conditioning in rats

JH Freeman Jr, S Barone Jr and ME Stanton
Journal of Neuroscience 1 November 1995, 15 (11) 7301-7314; DOI: https://doi.org/10.1523/JNEUROSCI.15-11-07301.1995
JH Freeman Jr
Department of Psychology, University of North Carolina at Chapel Hill 27599, USA.
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S Barone Jr
Department of Psychology, University of North Carolina at Chapel Hill 27599, USA.
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ME Stanton
Department of Psychology, University of North Carolina at Chapel Hill 27599, USA.
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Abstract

This study represents an attempt to establish a relationship between maturation of the cerebellum and the ontogeny of eyeblink conditioning in the rat. Experiments 1 and 2 examined the effects of disrupting cerebellar maturation by neonatal exposure to the antimitotic agent methylazoxymethanol (MAM) on the ontogeny of eyeblink conditioning in infant rats. Experiment 1 demonstrated that neonatal exposure to MAM on Postnatal Day 4 (PND4) and 7 severely disrupted cerebellar maturation. This effect appeared to be specific in that there was no overt dysmorphology in other brain regions. MAM treatment also severely disrupted associative eyeblink conditioning in rats given training on PND24 and 25. However, exposure to MAM had no effect on the unconditioned response, T-maze delayed alternation, or conditioned suppression of ongoing behavior. In Experiment 2, MAM was given on PND4 and 7 and pups were tested behaviorally on PND17–18, 20–21, or 31–32. Cerebellar hypoplasia was most dramatic shortly after exposure. The cerebellar cortex continued to mature after exposure to MAM, but development of morphological endpoints examined here were static from PND19 to 33. Eyeblink conditioning was impaired at all ages, indicating that there was no functional recovery following neonatal exposure to MAM over the age range tested. These experiments suggest that normal cerebellar maturation may be important for the ontogeny of eyeblink conditioning.

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The Journal of Neuroscience: 15 (11)
Journal of Neuroscience
Vol. 15, Issue 11
1 Nov 1995
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Disruption of cerebellar maturation by an antimitotic agent impairs the ontogeny of eyeblink conditioning in rats
JH Freeman Jr, S Barone Jr, ME Stanton
Journal of Neuroscience 1 November 1995, 15 (11) 7301-7314; DOI: 10.1523/JNEUROSCI.15-11-07301.1995

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Disruption of cerebellar maturation by an antimitotic agent impairs the ontogeny of eyeblink conditioning in rats
JH Freeman Jr, S Barone Jr, ME Stanton
Journal of Neuroscience 1 November 1995, 15 (11) 7301-7314; DOI: 10.1523/JNEUROSCI.15-11-07301.1995
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