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The behavior of APO-SUS rats in animal models with construct validity for schizophrenia

BA Ellenbroek, MA Geyer and AR Cools
Journal of Neuroscience 1 November 1995, 15 (11) 7604-7611; DOI: https://doi.org/10.1523/JNEUROSCI.15-11-07604.1995
BA Ellenbroek
Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands.
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MA Geyer
Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands.
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AR Cools
Department of Psychoneuropharmacology, University of Nijmegen, The Netherlands.
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Abstract

Schizophrenic patients are known to suffer from a number of information processing disturbances, including deficits in both prepulse inhibition of startle and latent inhibition. Since these behavioral phenomena can also be observed in animals, they represent an ideal starting point for developing animal models having construct validity for specific deficits observed in schizophrenia. The principal question is how to induce a condition in animals most similar to the schizophrenic deficit. In the present study, we have selected rats on the basis of their response to an open filed or to the dopaminergic agonist apomorphine, and evaluated their prepulse inhibition and latent inhibition. We used three different selection procedures (open field selection for novelty response, gnawing cage selection for apomorphine response, and pharmacogenetic selection for apomorphine response). The results show that, irrespective of the selection procedure used, rats with a high response to novelty or apomorphine susceptible (collectively called APO-SUS rats) show diminished prepulse inhibition of the acoustic startle response as compared to rats with a low response to novelty or apomorphine unsusceptible (collectively called APO-UNSUS rats). This difference was apparent only at low prepulse intensities. Moreover, these APO-SUS rats show diminished latent inhibition in a conditioned taste aversion paradigm as compared to APO- UNSUS rats. Given the fact that the pharmacogenetically bred APO-SUS rats show several central nervous, endocrinological, and immunological similarities to schizophrenic patients, they are hypothesised to represent an interesting nonpharmacological animal model for schizophrenia-prone patients.

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The Journal of Neuroscience: 15 (11)
Journal of Neuroscience
Vol. 15, Issue 11
1 Nov 1995
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The behavior of APO-SUS rats in animal models with construct validity for schizophrenia
BA Ellenbroek, MA Geyer, AR Cools
Journal of Neuroscience 1 November 1995, 15 (11) 7604-7611; DOI: 10.1523/JNEUROSCI.15-11-07604.1995

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The behavior of APO-SUS rats in animal models with construct validity for schizophrenia
BA Ellenbroek, MA Geyer, AR Cools
Journal of Neuroscience 1 November 1995, 15 (11) 7604-7611; DOI: 10.1523/JNEUROSCI.15-11-07604.1995
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