Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

Y Sagot; M Dubois-Dauphin; SA Tan; F de Bilbao; P Aebischer; JC Martinou; AC Kato

doi:10.1523/JNEUROSCI.15-11-07727.1995

Article Information

DOI

https://doi.org/10.1523/JNEUROSCI.15-11-07727.1995

PubMed

7472523

Published By

Society for Neuroscience

History

First published November 1, 1995.

Version of record published November 1, 1995.

Author Information

Y Sagot,
M Dubois-Dauphin,
SA Tan,
F de Bilbao,
P Aebischer,
JC Martinou, and
AC Kato

Department of Pharmacology, Centre Medical Universitaire, Geneva, Switzerland.

Author contributions

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	Abstract	Full	Pdf
Jan 1999	3	0	0
Feb 1999	1	0	0
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Total 1999	13	0	0
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Feb 2000	5	0	0
May 2000	2	0	0
Jun 2000	1	0	0
Jul 2000	2	0	0
Aug 2000	1	0	0
Sep 2000	1	0	0
Oct 2000	2	0	0
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Dec 2000	1	0	0
Total 2000	19	0	0
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Mar 2001	2	0	0
Apr 2001	3	0	0
May 2001	1	0	0
Jul 2001	2	0	0
Aug 2001	3	0	0
Sep 2001	2	0	0
Oct 2001	4	0	0
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Total 2001	23	0	0
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Mar 2002	6	0	0
Apr 2002	2	0	0
May 2002	7	0	0
Jun 2002	2	0	0
Jul 2002	3	0	0
Aug 2002	2	0	0
Sep 2002	8	0	0
Oct 2002	4	0	0
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Dec 2002	3	0	0
Total 2002	53	0	0
Jan 2003	4	0	0
Feb 2003	3	0	0
Mar 2003	1	0	0
Apr 2003	4	0	0
May 2003	1	0	0
Jun 2003	2	0	0
Jul 2003	12	0	0
Aug 2003	8	0	0
Sep 2003	6	0	0
Oct 2003	5	0	0
Nov 2003	14	0	7
Dec 2003	16	0	2
Total 2003	76	0	9
Jan 2004	10	0	3
Feb 2004	8	0	4
Mar 2004	10	0	1
Apr 2004	15	0	9
May 2004	10	0	14
Jun 2004	10	0	1
Jul 2004	10	0	8
Aug 2004	11	0	5
Sep 2004	11	0	16
Oct 2004	12	0	10
Nov 2004	12	0	4
Dec 2004	14	0	4
Total 2004	133	0	79
Jan 2005	12	0	2
Feb 2005	17	0	14
Mar 2005	18	0	12
Apr 2005	8	0	6
May 2005	8	0	3
Jun 2005	2	0	14
Jul 2005	3	0	6
Aug 2005	2	0	2
Sep 2005	5	0	12
Oct 2005	1	0	9
Nov 2005	6	0	10
Dec 2005	1	0	6
Total 2005	83	0	96
Jan 2006	7	0	8
Feb 2006	4	0	7
Mar 2006	7	0	14
Apr 2006	2	0	14
May 2006	2	0	10
Jun 2006	4	0	7
Jul 2006	2	0	8
Aug 2006	1	0	1
Sep 2006	4	0	8
Oct 2006	11	0	11
Nov 2006	9	0	7
Dec 2006	2	0	9
Total 2006	55	0	104
Jan 2007	4	0	9
Feb 2007	8	0	12
Mar 2007	4	0	8
Apr 2007	3	0	14
May 2007	2	0	9
Jun 2007	3	0	6
Jul 2007	3	0	5
Aug 2007	2	0	3
Sep 2007	1	0	10
Oct 2007	3	0	10
Nov 2007	10	0	13
Dec 2007	7	0	3
Total 2007	50	0	102
Jan 2008	9	0	14
Feb 2008	5	0	9
Mar 2008	9	0	8
Apr 2008	12	0	16
May 2008	5	0	5
Jun 2008	14	0	14
Jul 2008	3	0	7
Aug 2008	4	0	5
Sep 2008	11	0	15
Oct 2008	12	0	8
Nov 2008	15	0	11
Dec 2008	8	0	7
Total 2008	107	0	119
Jan 2009	3	0	11
Feb 2009	5	0	21
Mar 2009	6	0	26
Apr 2009	4	0	10
May 2009	17	0	19
Jun 2009	3	0	7
Jul 2009	3	0	19
Aug 2009	3	0	6
Sep 2009	4	0	16
Oct 2009	6	0	7
Nov 2009	7	0	2
Dec 2009	8	0	1
Total 2009	69	0	145
Jan 2010	4	0	9
Feb 2010	2	0	5
Mar 2010	4	0	8
Apr 2010	5	0	17
May 2010	5	0	26
Jun 2010	1	0	9
Jul 2010	7	0	10
Aug 2010	7	0	8
Sep 2010	4	0	13
Oct 2010	1	0	13
Nov 2010	3	0	19
Dec 2010	26	0	19
Total 2010	69	0	156
Jan 2011	15	0	13
Feb 2011	5	0	2
Mar 2011	6	0	19
Apr 2011	6	0	13
May 2011	4	0	6
Jun 2011	5	0	4
Jul 2011	2	0	8
Aug 2011	14	0	5
Sep 2011	8	0	5
Oct 2011	7	0	16
Nov 2011	12	0	8
Dec 2011	8	0	12
Total 2011	92	0	111
Jan 2012	9	0	16
Feb 2012	12	0	12
Mar 2012	17	0	27
Apr 2012	21	0	17
May 2012	8	0	7
Jun 2012	7	0	15
Jul 2012	7	0	10
Aug 2012	9	0	11
Sep 2012	13	0	10
Oct 2012	10	0	16
Nov 2012	25	0	9
Dec 2012	31	0	9
Total 2012	169	0	159
Jan 2013	14	0	19
Feb 2013	20	0	11
Mar 2013	16	0	14
Apr 2013	21	0	12
May 2013	70	0	11
Jun 2013	6	0	5
Jul 2013	7	0	15
Aug 2013	5	0	5
Sep 2013	5	0	10
Oct 2013	5	0	8
Nov 2013	5	0	8
Dec 2013	7	0	3
Total 2013	181	0	121
Jan 2014	9	0	6
Feb 2014	2	0	4
Mar 2014	5	0	7
Apr 2014	9	0	7
May 2014	10	0	6
Jun 2014	7	0	9
Jul 2014	10	0	8
Aug 2014	5	0	8
Sep 2014	6	0	1
Oct 2014	5	0	7
Nov 2014	6	0	8
Dec 2014	7	0	10
Total 2014	81	0	81
Jan 2015	5	0	7
Feb 2015	7	0	4
Mar 2015	20	0	6
Apr 2015	7	0	2
May 2015	8	0	9
Jun 2015	12	0	14
Jul 2015	6	0	2
Aug 2015	7	0	9
Sep 2015	5	0	4
Oct 2015	3	0	6
Nov 2015	12	0	17
Dec 2015	8	0	8
Total 2015	100	0	88
Jan 2016	3	0	10
Feb 2016	10	0	13
Mar 2016	11	0	19
Apr 2016	6	0	15
May 2016	0	0	11
Jun 2016	8	0	9
Jul 2016	6	0	9
Aug 2016	1	0	4
Sep 2016	5	1	4
Oct 2016	2	0	7
Nov 2016	9	0	11
Dec 2016	7	0	1
Total 2016	68	1	113
Jan 2017	8	0	8
Feb 2017	14	0	2
Mar 2017	16	0	7
Apr 2017	8	0	7
May 2017	45	0	7
Jun 2017	7	0	6
Jul 2017	18	0	15
Aug 2017	6	0	2
Sep 2017	5	0	4
Oct 2017	11	0	8
Nov 2017	14	0	7
Dec 2017	5	0	17
Total 2017	157	0	90
Jan 2018	4	0	2
Feb 2018	11	0	9
Mar 2018	4	0	4
Apr 2018	13	0	4
May 2018	13	0	7
Jun 2018	11	0	8
Jul 2018	11	0	3
Aug 2018	13	0	4
Sep 2018	15	0	5
Oct 2018	15	0	1
Nov 2018	13	0	3
Dec 2018	6	0	2
Total 2018	129	0	52
Jan 2019	2	0	1
Feb 2019	11	0	3
Mar 2019	18	0	9
Apr 2019	18	0	6
May 2019	13	0	4
Jun 2019	7	0	6
Jul 2019	4	0	6
Aug 2019	8	0	7
Sep 2019	13	0	4
Oct 2019	34	0	7
Nov 2019	20	0	8
Dec 2019	8	0	4
Total 2019	156	0	65
Jan 2020	11	0	2
Feb 2020	14	0	3
Mar 2020	5	0	3
Apr 2020	4	0	3
May 2020	5	0	3
Jun 2020	5	0	5
Jul 2020	9	0	1
Aug 2020	4	0	1
Sep 2020	22	0	9
Oct 2020	15	0	8
Nov 2020	21	0	9
Dec 2020	17	0	4
Total 2020	132	0	51
Jan 2021	34	0	2
Feb 2021	21	0	5
Mar 2021	26	0	13
Apr 2021	14	0	4
May 2021	25	0	1
Jun 2021	27	0	3
Jul 2021	14	0	11
Aug 2021	24	0	10
Sep 2021	17	0	8
Oct 2021	19	0	19
Nov 2021	15	0	17
Dec 2021	11	0	1
Total 2021	247	0	94
Jan 2022	15	0	6
Feb 2022	8	0	4
Mar 2022	21	0	9
Apr 2022	19	0	3
May 2022	9	0	4
Total 2022	72	0	26
Total	2334	1	1861