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A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes

E Zellmer, Z Zhang, D Greco, J Rhodes, S Cassel and EJ Lewis
Journal of Neuroscience 1 December 1995, 15 (12) 8109-8120; https://doi.org/10.1523/JNEUROSCI.15-12-08109.1995
E Zellmer
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA.
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Z Zhang
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA.
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D Greco
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA.
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J Rhodes
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA.
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S Cassel
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA.
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EJ Lewis
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA.
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Abstract

In order to characterize the specificity of expression of the neurotransmitter biosynthetic gene dopamine beta-hydroxylase (DBH), the identification of proteins that interact with the DB1 enhancer was initiated. A homeobox-containing cDNA was isolated from a PC12 expression cDNA library screened with the DB1 enhancer. The homeodomain is a member of the paired-like class, and is encoded by several nonidentical cDNAs. The cDNAs contain the same sequence in the homeodomain and 3′ coding and noncoding sequences, but diverge in sequence 5′ to the homeodomain. This family of homeobox-containing cDNAs is named Arix. Arix mRNA transcripts are found only in noradrenergic, DBH-positive tissues, and in cell lines derived from those tissue. The DB1 enhancer contains two binding sites for the Arix homeodomain, and both sites contribute to basal activity of the DBH promoter. When introduced into tissue culture, Arix regulates the transcriptional activity from the DBH promoter, and also from the promoter of the tyrosine hydroxylase gene, encoding the initial enzyme of the catecholamine biosynthetic pathway. The pattern of expression of the Arix transcripts, the presence of the homeodomain, and the transcriptional regulatory properties suggest that this family of proteins may be involved in the specificity of expression of the catecholamine biosynthetic genes.

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The Journal of Neuroscience: 15 (12)
Journal of Neuroscience
Vol. 15, Issue 12
1 Dec 1995
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A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes
E Zellmer, Z Zhang, D Greco, J Rhodes, S Cassel, EJ Lewis
Journal of Neuroscience 1 December 1995, 15 (12) 8109-8120; DOI: 10.1523/JNEUROSCI.15-12-08109.1995

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A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes
E Zellmer, Z Zhang, D Greco, J Rhodes, S Cassel, EJ Lewis
Journal of Neuroscience 1 December 1995, 15 (12) 8109-8120; DOI: 10.1523/JNEUROSCI.15-12-08109.1995
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