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TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons

DM Holtzman, J Kilbridge, Y Li, ET Cunningham Jr, NJ Lenn, DO Clary, LF Reichardt and WC Mobley
Journal of Neuroscience 1 February 1995, 15 (2) 1567-1576; DOI: https://doi.org/10.1523/JNEUROSCI.15-02-01567.1995
DM Holtzman
Department of Neurology, University of California at San Francisco 94143.
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J Kilbridge
Department of Neurology, University of California at San Francisco 94143.
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Y Li
Department of Neurology, University of California at San Francisco 94143.
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ET Cunningham Jr
Department of Neurology, University of California at San Francisco 94143.
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NJ Lenn
Department of Neurology, University of California at San Francisco 94143.
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DO Clary
Department of Neurology, University of California at San Francisco 94143.
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LF Reichardt
Department of Neurology, University of California at San Francisco 94143.
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WC Mobley
Department of Neurology, University of California at San Francisco 94143.
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Abstract

NGF acts as a neurotrophic factor by binding and activating its receptor on certain neuronal populations in the CNS and PNS. TrkA is a receptor for NGF. Recent findings in vitro indicate that this NGF- activated receptor tyrosine kinase transduces the NGF signal. To further define NGF actions in the CNS, we examined trkA expression in the adult rat brain. We found that trkA mRNA and immunoreactivity (IR) coincided in specific, defined neuronal populations in the forebrain and brainstem. In addition to cholinergic neurons in the basal forebrain and neostriatum, trkA expression was found in noncholinergic neurons in (1) the paraventricular anterior and reuniens thalamic nuclei, (2) the rostral and intermediate subnuclei of the interpeduncular nucleus (IPN), (3) scattered neurons in the ventrolateral and paramedian medulla, (4) the prepositus hypoglossal nucleus, and (5) the area postrema. NGF responsiveness was demonstrated for each of these populations. In contrast to trkA, p75NGFR was found only in a minority of NGF-responsive populations. Our data provide further evidence that expression of trkA marks NGF-responsive CNS neurons and suggests novel roles for NGF in the brain.

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The Journal of Neuroscience: 15 (2)
Journal of Neuroscience
Vol. 15, Issue 2
1 Feb 1995
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TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons
DM Holtzman, J Kilbridge, Y Li, ET Cunningham Jr, NJ Lenn, DO Clary, LF Reichardt, WC Mobley
Journal of Neuroscience 1 February 1995, 15 (2) 1567-1576; DOI: 10.1523/JNEUROSCI.15-02-01567.1995

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TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons
DM Holtzman, J Kilbridge, Y Li, ET Cunningham Jr, NJ Lenn, DO Clary, LF Reichardt, WC Mobley
Journal of Neuroscience 1 February 1995, 15 (2) 1567-1576; DOI: 10.1523/JNEUROSCI.15-02-01567.1995
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